XY153 is a BD2-selective BET inhibitor that primarily targets the bromodomain 2 (BD2) of the BRD4 protein. It exhibits potent binding affinity to BRD4 BD2, BRD3 BD2, and BRD2 BD2, with IC50 values of 0.79 nM, 5.31 nM, and 5.09 nM, respectively. XY153 demonstrates significant antiproliferative effects across various tumor cell lines and is applicable in research focused on acute myeloid leukemia (AML) and cancer therapeutics.
XY153 is a BD2-selective BET inhibitor that primarily targets the bromodomain 2 (BD2) of the BRD4 protein. It exhibits potent binding affinity to BRD4 BD2, BRD3 BD2, and BRD2 BD2, with IC50 values of 0.79 nM, 5.31 nM, and 5.09 nM, respectively. XY153 demonstrates significant antiproliferative effects across various tumor cell lines and is applicable in research focused on acute myeloid leukemia (AML) and cancer therapeutics.
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