h-NTPDase-IN-4 is a potent pan-inhibitor of NTPDase, demonstrating IC50 values of 3.58 μM against h-NTPDase1, 10.21 μM against h-NTPDase2, 0.13 μM against h-NTPDase3, and 13.57 μM against h-NTPDase8. This compound selectively modulates nucleotide metabolism and purinergic signaling pathways, making it a valuable tool for research in cellular communication, inflammation, and cancer biology. Its broad activity across multiple NTPDase isoforms positions it as a significant reagent for studies investigating the role of purinergic receptors in various physiological and pathological processes.
h-NTPDase-IN-4 is a potent pan-inhibitor of NTPDase, demonstrating IC50 values of 3.58 μM against h-NTPDase1, 10.21 μM against h-NTPDase2, 0.13 μM against h-NTPDase3, and 13.57 μM against h-NTPDase8. This compound selectively modulates nucleotide metabolism and purinergic signaling pathways, making it a valuable tool for research in cellular communication, inflammation, and cancer biology. Its broad activity across multiple NTPDase isoforms positions it as a significant reagent for studies investigating the role of purinergic receptors in various physiological and pathological processes.
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