h-NTPDase-IN-5 is a pan-inhibitor of NTPDase enzymes, demonstrating IC50 values of 1.10 μM for h-NTPDase1, 44.73 μM for h-NTPDase2, 26.14 μM for h-NTPDase3, and 0.32 μM for h-NTPDase8. This compound effectively modulates ATP metabolism by targeting ecto-nucleotide triphosphate diphosphohydrolases, making it a valuable tool for investigating purinergic signaling pathways. Its inhibitory profile supports research applications in cell signaling, neurobiology, and the study of various pathophysiological conditions related to nucleotide signaling.
h-NTPDase-IN-5 is a pan-inhibitor of NTPDase enzymes, demonstrating IC50 values of 1.10 μM for h-NTPDase1, 44.73 μM for h-NTPDase2, 26.14 μM for h-NTPDase3, and 0.32 μM for h-NTPDase8. This compound effectively modulates ATP metabolism by targeting ecto-nucleotide triphosphate diphosphohydrolases, making it a valuable tool for investigating purinergic signaling pathways. Its inhibitory profile supports research applications in cell signaling, neurobiology, and the study of various pathophysiological conditions related to nucleotide signaling.
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