Fig. 1 · Structure
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Halofuginone hydrobromide
Prolyl-tRNA Synthetase Inhibitor
Halofuginone hydrobromide is a competitive inhibitor of prolyl-tRNA synthetase with a Ki value of 18.3 nM. It is known to specifically inhibit type-I collagen synthesis and reduce osteoarthritis symptoms through the attenuation of TGF-β activity. Additionally, Halofuginone hydrobromide acts as a potent pulmonary vasodilator by activating Kv channels while simultaneously blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels. It exhibits a range of biological activities including anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrotic effects, making it relevant for various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 64924-67-0 |
| Applications | Prolyl-tRNA Synthetase Inhibitor |
| Formula | C16H18Br2ClN3O3 |
| Molecular Weight | 495.59 |
| Synonyms | RU-19110 hydrobromide |
| SMILES | O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.Br |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.