Fig. 1 · Structure
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Halofuginone hydrochloride
Prolyl-tRNA Synthetase Inhibitor
Halofuginone hydrochloride is a competitive inhibitor of prolyl-tRNA synthetase, exhibiting a Ki of 18.3 nM. This compound specifically inhibits type-I collagen synthesis and mitigates osteoarthritis by suppressing TGF-β activity. Additionally, Halofuginone hydrochloride functions as a potent pulmonary vasodilator through the activation of Kv channels while blocking voltage-gated, receptor-operated, and store-operated Ca2+ channels. It has demonstrated significant anti-malaria, anti-inflammatory, anti-cancer, and anti-fibrotic properties, making it valuable for various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1217623-74-9 |
| Applications | Prolyl-tRNA Synthetase Inhibitor |
| Formula | C16H18BrCl2N3O3 |
| Molecular Weight | 451.14 |
| Synonyms | RU-19110 hydrochloride |
| SMILES | O=C1C2=CC(Cl)=C(Br)C=C2N=CN1CC(C[C@H]3[C@@H](CCCN3)O)=O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.