Harman-13C2,15N is a stable isotope-labeled derivative of Harmane, a known benzodiazepine receptor antagonist (IC50 = 7 μM). This compound exhibits notable affinity for various biological targets, including mACh (IC50 = 24 μM), Opioid Receptor (IC50 = 2.8 μM), MAO-A/B (IC50 = 0.5 μM), and the α2-adrenergic receptor (IC50 = 5 μM). Harmane is recognized for its diverse pharmacological activities, such as reducing blood pressure via I1 imidazoline receptor inhibition (IC50 = 30 nM), as well as demonstrating antidepressant, anti-anxiety, anticonvulsant, and analgesic properties. Additionally, it has been shown to affect dopamine biosynthesis and enhance mutagenic effects in specific cellular assays.
Harman-13C2,15N is a stable isotope-labeled derivative of Harmane, a known benzodiazepine receptor antagonist (IC50 = 7 μM). This compound exhibits notable affinity for various biological targets, including mACh (IC50 = 24 μM), Opioid Receptor (IC50 = 2.8 μM), MAO-A/B (IC50 = 0.5 μM), and the α2-adrenergic receptor (IC50 = 5 μM). Harmane is recognized for its diverse pharmacological activities, such as reducing blood pressure via I1 imidazoline receptor inhibition (IC50 = 30 nM), as well as demonstrating antidepressant, anti-anxiety, anticonvulsant, and analgesic properties. Additionally, it has been shown to affect dopamine biosynthesis and enhance mutagenic effects in specific cellular assays.
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