HDAC8/BRPF1-IN-1 is a dual inhibitor targeting HDAC8 and BRPF1, demonstrating an IC50 of 443 nM for HDAC8 and a Kd of 67 nM for BRPF1 in human cells. This compound exhibits minimal activity against HDAC1 and HDAC6, making it a selective tool for probing histone deacetylation pathways. It is valuable for investigating the roles of HDAC8 and BRPF1 in gene regulation and potential therapeutic strategies in cancer research.
HDAC8/BRPF1-IN-1 is a dual inhibitor targeting HDAC8 and BRPF1, demonstrating an IC50 of 443 nM for HDAC8 and a Kd of 67 nM for BRPF1 in human cells. This compound exhibits minimal activity against HDAC1 and HDAC6, making it a selective tool for probing histone deacetylation pathways. It is valuable for investigating the roles of HDAC8 and BRPF1 in gene regulation and potential therapeutic strategies in cancer research.
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