FAP | Adooq Bioscience

Cat. No.: A31454

CAS No.: 668435-69-6

TFAP2β modulator-1

TFAP2β modulator-1 is a potent modulator of the transcription factor TFAP2β, promoting its condensation through the induction of conformational changes within its intrinsically disordered region. This compound exhibits significant anti-tumor activity by inducing apoptosis in esophageal squamous cell carcinoma (ESCC) cells, as well as in relevant mouse models and organoids. TFAP2β modulator-1 serves as a valuable tool for investigating the role of TFAP2β in ESCC research and therapeutic development.

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Cat. No.: A62990

CAS No.: 115406-25-2

R-75317

R-75317 is a selective antagonist of platelet-activating factor (PAF). It has demonstrated the ability to prevent the decline in creatinine clearance in a rat model of antibody-induced glomerulonephritis, delay the onset of proteinuria, and ameliorate glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. This compound may serve as a valuable tool in the investigation of glomerulonephritis and related renal pathologies.

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Cat. No.: A64613

CAS No.: 80049-85-0

Suc-Gly-Pro-AMC

Suc-Gly-Pro-AMC is a fluorescent substrate designed specifically for the fibroblast activation protein (FAP). It is capable of reacting with recombinant porcine prolyl oligopeptidase, facilitating the study of FAP and prolyl endopeptidase (PREP) activity. This reagent is particularly valuable in glioma research, providing insights into the enzymatic functions associated with tumor progression and microenvironmental interactions.

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2 mg

$65.00

5 mg

$100.00

All 6 sizes

Cat. No.: A64622

CAS No.: 1426305-25-0

ARI-3144

ARI-3144 is a specific substrate for fibroblast activation protein (FAP), designed for effective detection and quantification. When coupled with the fluorophore 7-Amino-4-methylcoumarin (AMC), this substrate facilitates sensitive analysis of FAP activity in various biological samples. ARI-3144 is valuable in research applications related to cancer biology and tissue remodeling, enabling deeper insights into FAP functions and its role in disease progression.

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5 mg

$335.00

10 mg

$515.00

All 5 sizes

Cat. No.: B18381

CAS No.: 701245-29-6

SID 125240931

SID 125240931 is a modulator of fluorogen activating proteins (FAPs), primarily targeting the interaction between fluorogens and FAP. This compound is designed to disrupt binding affinity, providing insights into FAP-mediated processes. It has potential applications in cellular imaging and monitoring protein interactions, making it a valuable tool for researchers in cell biology and molecular imaging studies.

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5 mg

$80.00

10 mg

$125.00

All 5 sizes