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Interleukin (IL) receptor modulators act on cytokine signaling through shared receptor chains or interleukin production. Many interleukin receptors share signaling subunits, such as glycoprotein 130 (gp130) used by IL-6 and related cytokines. SC-144 binds gp130 and blocks signaling downstream of this subunit. IL-12 and IL-23 share a p40 subunit, which pairs with p35 in IL-12 and with p19 in IL-23. Apilimod inhibits production of both cytokines and suppresses T helper 1 (Th1) responses in cell and animal models. Suplatast tosilate reduces IL-4 and IL-5 production by T helper 2 cells, and IX 207-887 inhibits IL-1 release.
Synonyms: Imunovir; Delimmun; Groprinosin
Inosine pranobex is a potent, broad-spectrum antiviral compound for HIV infection. Inosine pranobex is an immunopotentiator.
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
Synonyms: NPT-15392 racemate; NPT15392
Nosantine racemate is the racemate of Nosantine. Nosantine is an inducer of IL-2 or enhancer of IL-2 induction by phytohemagglutinin (PHA).
IL-17A modulator-3 is a selective modulator targeting IL-17A. This compound demonstrates effective inhibition of the IL-17A/A receptor complex with an IC50 value of less than 10 μM. It is suitable for research applications related to inflammation, cancer biology, and autoimmune disorders, providing valuable insights into these critical areas of study.
IL-17 Modulator 4 is a proagent of IL-17 Modulator 1, serving as an IL-17 inhibitor targeting the interleukin-17 pathway. This compound exhibits potent modulation of IL-17A and is significant for research into IL-17A mediated diseases, including various inflammatory and autoimmune conditions, as well as infectious diseases and cancer. Its application in preclinical studies may enhance understanding of the therapeutic potential in these pathologies.
IL-17 modulator 3 is a specific IL-17 modulator that targets the IL-17 signaling pathway, playing an essential role in immune regulation. It exhibits potential anti-inflammatory properties and is valuable for research into inflammatory conditions, cancer, and autoimmune diseases. This compound offers insights into the modulation of IL-17 related pathways in various biological contexts.
GP130 modulator-1 is a potent modulator of the GP130 signaling pathway, crucial for mediating responses to interleukin-6 family cytokines. This compound demonstrates significant biological activity in the attenuation of inflammatory responses, making it a valuable tool for investigating inflammatory and degenerative disorders. Researchers can utilize GP130 modulator-1 to explore mechanisms of pathogenesis and therapeutic strategies in relevant biological models.
IL-17A modulator-2 selectively targets interleukin-17A (IL-17A), functioning as a potent inhibitor with a pIC50 of 8.3. This compound effectively modulates the biological activity of IL-17A, making it valuable for research into a variety of conditions linked with IL-17A dysregulation. Applications include investigations into autoimmune diseases, cancers, and neurodegenerative disorders where IL-17A plays a significant role in pathogenesis.
IL-17A modulator-1 is a selective modulator of interleukin-17A (IL-17A) that inhibits its biological activity with a pIC50 of 8.2. This compound is valuable for research into diseases associated with dysregulation of IL-17A, including autoimmune disorders, cancers, and neurodegenerative diseases. Its ability to modulate IL-17A activity makes it a pertinent tool for studies investigating immune responses and therapeutic interventions.
(R)-IL-17 modulator 4 is a selective modulator of IL-17, functioning as a proagent for IL-17 modulator 1, a potent and orally active IL-17 inhibitor. This compound exhibits significant biological activity in the modulation of IL-17A signaling pathways, making it valuable in the study of IL-17A mediated diseases. Research applications include investigating its role in inflammation, autoimmune disorders, infectious diseases, cancer, and precancerous syndromes.
GP130 modulator-2 is a selective modulator of the glycoprotein 130 (GP130) signaling pathway. This compound plays a crucial role in regulating the signaling pathways associated with interleukin-6 (IL-6) family cytokines, influencing various biological processes. It is primarily utilized in research studying diseases linked to aberrant GP130 activity, including inflammatory and autoimmune disorders.
IL-17 Modulator 4 Sulfate targets the IL-17 signaling pathway, functioning as a proagent of IL-17 Modulator 1. This compound exhibits potent modulatory effects on IL-17A, making it a valuable tool for investigating IL-17A mediated diseases. Its applications extend across various fields, including inflammation, autoimmune disorders, infectious diseases, cancer, and precancerous syndromes, facilitating a deeper understanding of these conditions.
IL-17 Modulator 1 is a small molecule that selectively targets the IL-17 signaling pathway. This compound exhibits high efficacy in modulating IL-17 activity, making it valuable for studying inflammatory diseases. It is particularly relevant in research focusing on psoriasis, ankylosing spondylitis, and psoriatic arthritis, providing insights into mechanisms of disease prevention and treatment.
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IL-17 modulator 8 is an orally active modulator targeting interleukin-17 (IL-17). This compound significantly reduces pro-inflammatory cytokines such as IL-6 and IFN-γ, as well as edema. IL-17 modulator 8 is applicable in research focused on arthritis and related inflammatory diseases.
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IL-17 Modulator 2 is an orally active compound that targets the IL-17 pathway. It is effective in significantly reducing levels of pro-inflammatory cytokines, including IL-6 and IFN-γ, while also decreasing edema. This reagent is suited for research applications related to arthritis and other inflammatory conditions.
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