STING

Cat. No.

A24094

CAS No.

2767427-87-0

Anti-inflammatory agent 70

Synonyms: N-Me-SP23

Anti-inflammatory agent 70 (N-Me-SP23) is a PROTAC-based degrader targeting the STING (stimulator of interferon genes) protein, a key regulator of innate immune and inflammatory responses. By promoting STING degradation, N-Me-SP23 effectively inhibits the STING signaling pathway, leading to reduced downstream inflammatory cytokine production. This compound exhibits notable anti-inflammatory activity and holds potential for therapeutic research in STING-associated autoimmune and inflammatory disorders.

Cat. No.

A24690

CAS No.

2762552-74-7

PROTAC STING Degrader-1

PROTAC STING Degrader-1 is a PROTAC degrader designed to target the STING (Stimulator of Interferon Genes) pathway, demonstrating a DC50 value of 3.2 μM. It exhibits pronounced anti-inflammatory effects, making it a valuable tool for investigating conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). This compound can facilitate research into STING-mediated signaling and its role in various inflammatory processes.

Cat. No.

A65547

CAS No.

3030588-01-0

NVS-STG2

NVS-STG2 is a molecular glue that targets the STING receptor by binding to the interstitial regions of adjacent STING dimers, thereby enhancing STING signaling. This compound promotes the activity of cGAMP, leading to the formation of larger and more stable oligomers, which amplifies the immune response. NVS-STG2 has demonstrated significant antitumor effects in preclinical animal models, making it a valuable tool for cancer immunotherapy research.

Cat. No.

A65574

CAS No.

3109967-69-0

PROTAC STING degrader-3

PROTAC STING degrader-3 is a potent STING PROTAC degrader that operates through the ubiquitin-proteasome pathway, exhibiting a DC50 of 0.62 μM. This compound facilitates STING degradation, resulting in the inhibition of STING/TBK1/NF-κB signaling, thereby exerting notable anti-inflammatory effects. Additionally, PROTAC STING degrader-3 demonstrates renal protective properties and serves as a valuable tool for investigating acute kidney injury (AKI).

Cat. No.

A65611

CAS No.

3023095-61-3

PROTAC STING Degrader-2

PROTAC STING Degrader-2 is a targeted protein degrader that specifically induces the degradation of the Stimulator of Interferon Genes (STING) through a covalent interaction with STING and an E3 ubiquitin ligase. With a DC50 value of 0.53 μM, this compound facilitates the study of STING's biological functions, particularly in the context of autoinflammatory and autoimmune diseases. This reagent is instrumental for researchers exploring the therapeutic potential and role of STING in immune regulation.