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INT-777 (R-enantiomer)

Catalog No.: A60401
TGR5 Agonist
INT-777 (R-enantiomer) is a selective agonist of the TGR5 receptor, exhibiting an EC50 value of 4.79 μM. This compound plays a significant role in studying metabolic disorders and gastrointestinal physiology due to its activation of TGR5. Research applications include investigations into energy homeostasis, insulin sensitivity, and the modulation of bile acid signaling pathways.
INT-777 (R-enantiomer) 1198786-98-9 TGR5 Agonist
Grouped product items
Size Price Stock Qty
2mg
$345.00
In stock
5mg
$690.00
In stock
25mg
$1,530.00
In stock
50mg
$1,950.00
In stock
100mg
$2,480.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionINT-777 (R-enantiomer) is a selective agonist of the TGR5 receptor, exhibiting an EC50 value of 4.79 μM. This compound plays a significant role in studying metabolic disorders and gastrointestinal physiology due to its activation of TGR5. Research applications include investigations into energy homeostasis, insulin sensitivity, and the modulation of bile acid signaling pathways.
Product Information
Catalog NumA60401
FormulaC27H46O5
Molecular Weight450.65
CAS Number1198786-98-9
SMILESO[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1
SynonymsS-EMCA R enantiomer
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > GPCR19