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JAK-IN-31

Catalog No.: A33379
JAK Inhibitor
JAK-IN-31 is a potent JAK inhibitor targeting JAK1, JAK2, JAK3, and Tyk2 with IC50 values of ≤0.01 µM for JAK1, JAK2, and Tyk2, and 0.01-0.1 µM for JAK3. This compound demonstrates significant activity in inhibiting JAK signaling pathways, making it a valuable tool for investigating the role of JAKs in various cancers. JAK-IN-31 is suitable for applications in cancer research, particularly in studies focused on JAK-mediated signaling and its implications in tumor biology.
JAK-IN-31 2597016-88-9 JAK Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionJAK-IN-31 is a potent JAK inhibitor targeting JAK1, JAK2, JAK3, and Tyk2 with IC50 values of ≤0.01 µM for JAK1, JAK2, and Tyk2, and 0.01-0.1 µM for JAK3. This compound demonstrates significant activity in inhibiting JAK signaling pathways, making it a valuable tool for investigating the role of JAKs in various cancers. JAK-IN-31 is suitable for applications in cancer research, particularly in studies focused on JAK-mediated signaling and its implications in tumor biology.
Product Information
Catalog NumA33379
FormulaC21H19N7O2S2
Molecular Weight465.55
CAS Number2597016-88-9
SMILESCC1=NN=C(S1)C2=CN=C3C(C=CN3)=C2N[C@@H]4C[C@@H](C4)NS(=O)(C5=CC(C#N)=CC=C5)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Epigenetics > JAK
JAK/Stat > JAK