KMG-301AM is an acetoxymethyl ester of KMG-301 designed as a Mg2+ fluorescent probe targeting mitochondria. Upon accumulation within mitochondria, KMG-301AM is hydrolyzed to the active form, KMG-301, which is selective for Mg2+ detection in intact cells. This compound remains retained in the mitochondria due to the impermeable nature of the mitochondrial membrane, allowing it to reliably indicate variations in mitochondrial Mg2+ concentration and facilitate studies of Mg2+ transport across the mitochondrial membrane in cellular models.
KMG-301AM is an acetoxymethyl ester of KMG-301 designed as a Mg2+ fluorescent probe targeting mitochondria. Upon accumulation within mitochondria, KMG-301AM is hydrolyzed to the active form, KMG-301, which is selective for Mg2+ detection in intact cells. This compound remains retained in the mitochondria due to the impermeable nature of the mitochondrial membrane, allowing it to reliably indicate variations in mitochondrial Mg2+ concentration and facilitate studies of Mg2+ transport across the mitochondrial membrane in cellular models.
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