KRAS G12D inhibitor 19

Catalog No.: A63684
KRAS G12D inhibitor
KRAS G12D inhibitor 19 is a selective inhibitor targeting the KRAS G12D mutant protein, which plays a pivotal role in driving oncogenic signaling pathways in various cancers. This compound exhibits significant anti-proliferative activity against KRAS G12D-driven tumor cell lines. It serves as a valuable tool in cancer research, particularly for studying the efficacy of KRAS-targeted therapies and understanding the mechanistic pathways involved in KRAS-related malignancies.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS G12D inhibitor 19 is a selective inhibitor targeting the KRAS G12D mutant protein, which plays a pivotal role in driving oncogenic signaling pathways in various cancers. This compound exhibits significant anti-proliferative activity against KRAS G12D-driven tumor cell lines. It serves as a valuable tool in cancer research, particularly for studying the efficacy of KRAS-targeted therapies and understanding the mechanistic pathways involved in KRAS-related malignancies.
Product Information
Catalog NumA63684
FormulaC35H34F2N6O3
Molecular Weight624.68
CAS Number2833695-47-7
SMILESFC1=C(C#C)C2=C(C3=NC=C4C(N=C(OCC5(CC5)CN6[C@@H](C7)CO[C@@H]7C6)N=C4N8C[C@H]9N[C@H](CC9)C8)=C3F)C=C(O)C=C2C=C1
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