MRTX-EX185 is a selective inhibitor of KRAS(G12D) with an IC50 of 90 nM, effectively binding to both GDP-loaded and active GTP-bound states of KRAS. This compound demonstrates broad-spectrum activity against various KRAS mutations, including KRAS WT, KRAS (G12C), KRAS (Q61H), and KRAS (G13D), with IC50 values ranging from 110 nM to 290 nM. Additionally, MRTX-EX185 interacts with GDP-loaded HRAS. This reagent is valuable for investigating RAS-driven tumors, particularly in the context of pancreatic cancer research.
MRTX-EX185 is a selective inhibitor of KRAS(G12D) with an IC50 of 90 nM, effectively binding to both GDP-loaded and active GTP-bound states of KRAS. This compound demonstrates broad-spectrum activity against various KRAS mutations, including KRAS WT, KRAS (G12C), KRAS (Q61H), and KRAS (G13D), with IC50 values ranging from 110 nM to 290 nM. Additionally, MRTX-EX185 interacts with GDP-loaded HRAS. This reagent is valuable for investigating RAS-driven tumors, particularly in the context of pancreatic cancer research.
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