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KRAS G12D inhibitor 28

Catalog No.: A63707
KRAS G12D Inhibitor
KRAS G12D inhibitor 28 selectively targets the KRAS G12D mutation, a common oncogenic driver in various cancers. This compound exhibits potent inhibitory activity, making it a valuable tool for studying KRAS-driven tumor biology and developing targeted therapies. Its application in cancer research aids in understanding the molecular mechanisms of KRAS mutations and their role in tumor progression.
KRAS G12D inhibitor 28 2923669-28-5 KRAS G12D Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS G12D inhibitor 28 selectively targets the KRAS G12D mutation, a common oncogenic driver in various cancers. This compound exhibits potent inhibitory activity, making it a valuable tool for studying KRAS-driven tumor biology and developing targeted therapies. Its application in cancer research aids in understanding the molecular mechanisms of KRAS mutations and their role in tumor progression.
Product Information
Catalog NumA63707
FormulaC35H32Cl2FN5O
Molecular Weight628.57
CAS Number2923669-28-5
SMILESClC1=C(Cl)C(C2=C(F)C(N=C(C)C3=C4N([C@H]5[C@H]6CN[C@@H]5C6)C([C@@H]7N(C(C8CC8)=O)[C@H]9[C@H](C9)C7)=C3)=C4C=C2CCC#N)=CC=C1
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Cell Cycle > Ras