KRAS Inhibitor-15 is a selective inhibitor targeting the KRAS G12C mutation, exhibiting a potent IC50 of 0.954 µM. This compound demonstrates effective inhibition of phosphorylated ERK (p-ERK) with IC50 values of 2.03 µM in MIA PaCA-2 cells and >33.3 µM in A549 cells. KRAS Inhibitor-15 is suitable for investigating therapeutic strategies in pancreatic, colorectal, and lung cancers, contributing to the understanding of KRAS-driven tumorigenesis.
KRAS Inhibitor-15 is a selective inhibitor targeting the KRAS G12C mutation, exhibiting a potent IC50 of 0.954 µM. This compound demonstrates effective inhibition of phosphorylated ERK (p-ERK) with IC50 values of 2.03 µM in MIA PaCA-2 cells and >33.3 µM in A549 cells. KRAS Inhibitor-15 is suitable for investigating therapeutic strategies in pancreatic, colorectal, and lung cancers, contributing to the understanding of KRAS-driven tumorigenesis.
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