KRAS Inhibitor-16 is a selective inhibitor targeting the KRAS G12C mutation, demonstrating a potent activity with an IC50 of 0.457 µM. This compound effectively inhibits phosphorylated ERK in MIA PaCA-2 and A549 cell lines, with IC50 values of 3.06 µM and 11.1 µM, respectively. KRAS Inhibitor-16 is suitable for research applications focusing on pancreatic, colorectal, and lung cancers, contributing to the advancement of targeted therapies in these malignancies.
KRAS Inhibitor-16 is a selective inhibitor targeting the KRAS G12C mutation, demonstrating a potent activity with an IC50 of 0.457 µM. This compound effectively inhibits phosphorylated ERK in MIA PaCA-2 and A549 cell lines, with IC50 values of 3.06 µM and 11.1 µM, respectively. KRAS Inhibitor-16 is suitable for research applications focusing on pancreatic, colorectal, and lung cancers, contributing to the advancement of targeted therapies in these malignancies.
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