L-Asparagine-15N2,d8 is a stable isotope-labeled form of the essential amino acid L-Asparagine. This compound serves as a substrate for the enzyme L-Asparaginase, known for its anti-leukemic properties through the depletion of asparagine and glutamine. L-Asparaginase induces apoptosis in leukemic cells by inhibiting RNA and DNA synthesis, particularly in cancer cells with low expression of asparagine synthetase. Additionally, L-Asparagine can be utilized as a biomarker in research applications focused on childhood acute lymphoblastic leukemia.
L-Asparagine-15N2,d8 is a stable isotope-labeled form of the essential amino acid L-Asparagine. This compound serves as a substrate for the enzyme L-Asparaginase, known for its anti-leukemic properties through the depletion of asparagine and glutamine. L-Asparaginase induces apoptosis in leukemic cells by inhibiting RNA and DNA synthesis, particularly in cancer cells with low expression of asparagine synthetase. Additionally, L-Asparagine can be utilized as a biomarker in research applications focused on childhood acute lymphoblastic leukemia.
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