L-Asparagine-amide-15N monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine. It serves as an essential substrate for L-Asparaginase, an enzyme that depletes asparagine and glutamine levels, ultimately inhibiting protein biosynthesis in leukemic cells. This compound is instrumental in research applications targeting childhood acute lymphoblastic leukemia, where the depletion of asparagine leads to inhibited RNA and DNA synthesis, promoting apoptosis in cancer cells with low asparagine synthetase expression. Additionally, L-Asparagine monohydrate functions as a valuable biomarker and sensor in studies of leukemic cell metabolism.
L-Asparagine-amide-15N monohydrate is a stable isotope-labeled form of the amino acid L-Asparagine. It serves as an essential substrate for L-Asparaginase, an enzyme that depletes asparagine and glutamine levels, ultimately inhibiting protein biosynthesis in leukemic cells. This compound is instrumental in research applications targeting childhood acute lymphoblastic leukemia, where the depletion of asparagine leads to inhibited RNA and DNA synthesis, promoting apoptosis in cancer cells with low asparagine synthetase expression. Additionally, L-Asparagine monohydrate functions as a valuable biomarker and sensor in studies of leukemic cell metabolism.
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