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Other Lipids lists lipid-related compounds that fall outside the five main lipid classes of this section. Phenolic lipids are represented by 5-heptadecylresorcinol, an alkylresorcinol with a long saturated side chain that occurs in cereal bran. Linoleic acid derivatives include cis-coronaric acid, an epoxy fatty acid, and octadeca-9,12-dienamide, a primary fatty acid amide. 11-cis-Vaccenyl acetate is a fatty acyl ester that acts as a male pheromone in the fruit fly Drosophila melanogaster. ONO-4007 is a synthetic analog of lipid A, the glycolipid anchor of bacterial lipopolysaccharide. Riboflavin tetrabutyrate, a lipophilic ester of riboflavin (vitamin B2), is listed as well. Some entries are not lipids, such as plozasiran, a small interfering RNA (siRNA) directed at apolipoprotein C-III (APOC3).
Kihadanin B is a citrus limonoid known for its inhibitory action on lipid accumulation. It effectively suppresses adipogenesis by downregulating the Akt-FOXO1-PPARγ signaling pathway in 3T3-L1 adipocytes. This compound is valuable for research focused on obesity, metabolism, and related metabolic disorders.
3,4,5-Trihydroxycinnamic acid decyl ester is a potent pancreatic lipase inhibitor, demonstrating significant efficacy in lipid absorption and accumulation inhibition, with an EC50 of approximately 0.9 μM. This compound exhibits anti-obesity properties, making it a valuable reagent for research focused on metabolic disorders and lipid metabolism. Its ability to modify lipid absorption pathways underscores its potential applications in pharmacological studies targeting obesity and related conditions.
3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one is a selective inhibitor of lipid peroxidation. This compound demonstrates significant potential in combating oxidative stress, making it valuable for research into diseases such as cardiovascular disorders and neurodegenerative conditions. Its ability to modulate lipid peroxidation pathways positions it as a useful tool for investigating cellular mechanisms associated with oxidative damage.
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ML261 is a potent inhibitor of hepatic lipid droplet formation, exhibiting an IC50 value of 69.7 nM. This compound is valuable for research into non-alcoholic fatty liver disease (NAFLD) and related inflammatory processes, allowing for exploration of therapeutic strategies targeting lipid metabolism and hepatic function.
Phenochalasin A is a lipid droplets inhibitor that effectively reduces both the number and size of lipid droplets in macrophages at concentrations below 20 μM. This compound demonstrates a lack of cytotoxicity, making it a valuable tool for studying lipid metabolism and the role of lipid droplets in cellular processes. Phenochalasin A is applicable in research focused on metabolic disorders and related therapeutic developments.
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