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Biological Activity
Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, and increase gastrointestinal transit.
Targets
| ClC-2 chloride channels | ||||
| In vitro | DMSO | 76 mg/mL (194.64 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL (194.64 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.61 mL | 128.05 mL | 256.11 mL |
| 0.5 mM | 5.12 mL | 25.61 mL | 51.22 mL |
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
*The above data is based on the productmolecular weight 390.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10540 |
|---|---|
| CAS No. | 136790-76-6 |
| Formula | C20H32F2O5 |
| M. Wt | 390.46 |
| Purity | >98% |
| Synonyms | Amitiza, RU-0211, SPI-0211 |
| SMILES | CCCCC([[email protected]]1(CC[[email protected]]2[[email protected]](O1)CC(=O)[[email protected]@H]2CCCCCCC(=O)O)O)(F)F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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