LXY3 is a VLA-3-blocking peptide that inhibits the interaction between the integrin α3β1 (VLA-3) present on neutrophils and laminin in the basement membrane. By obstructing this interaction, LXY3 effectively prevents neutrophil migration across the tumor vascular basement membrane barrier, thereby mitigating neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. This peptide is particularly useful in targeted imaging studies related to breast cancer.
LXY3 is a VLA-3-blocking peptide that inhibits the interaction between the integrin α3β1 (VLA-3) present on neutrophils and laminin in the basement membrane. By obstructing this interaction, LXY3 effectively prevents neutrophil migration across the tumor vascular basement membrane barrier, thereby mitigating neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. This peptide is particularly useful in targeted imaging studies related to breast cancer.
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