p38-MAPK

Cat. No.

A15680

CAS No.

521-32-4

Bilobetin

Bilobetin acts as a PPARα activator, enhancing lipid metabolism and insulin sensitivity. It effectively reduces blood lipid levels by promoting hepatic lipid uptake and oxidation, while decreasing triglyceride secretion and accumulation in tissues. Additionally, Bilobetin stimulates the phosphorylation and nuclear translocation of PPARα, resulting in increased cAMP levels and PKA activity. This compound is significant for research in metabolic disorders, particularly those related to insulin resistance and lipid regulation.

Cat. No.

A30754

CAS No.

1110905-26-4

MTBT

MTBT is a p38 MAPK activator with notable anticancer properties. It effectively inhibits tumor cell proliferation, inducing cell cycle arrest and apoptosis. MTBT enhances the phosphorylation of histone H3 at serine residues in cancer cells, thereby facilitating cell cycle arrest in the M phase. The specific p38 MAPK inhibitor Adezmapimod can reverse the cell cycle arrest effects initiated by MTBT, making it a valuable tool in cancer research and therapeutic studies.

Cat. No.

A37534

CAS No.

276690-61-0

Iroxanadine sulfate

Synonyms: (-)-BRX 005 sulfate; (-)-BRX 235 sulfate

Iroxanadine sulfate is a dual activator of p38 kinase and heat shock protein (HSP), functioning as a vasculoprotector. This compound exhibits significant biological activity relevant to vascular health and has potential applications in the study of atherosclerosis and other vascular diseases. Researchers may utilize Iroxanadine sulfate to explore therapeutic strategies aimed at modulating p38 and HSP signaling pathways in various models of vascular pathology.

Cat. No.

A37628

CAS No.

203805-20-3

(±)-Iroxanadine (BRX 005, BRX 235)

Synonyms: BRX 005; BRX 235

(±)-Iroxanadine serves as a p38 kinase and heat shock protein (HSP) activator, demonstrating vasculoprotective properties. This compound is pertinent for research into atherosclerosis and various vascular diseases, facilitating studies aimed at understanding the molecular mechanisms underlying these conditions. Its activation of key signaling pathways makes it a valuable tool for exploring therapeutic targets in cardiovascular research.

Cat. No.

A37632

CAS No.

276690-59-6

Iroxanadine hydrochloride

Synonyms: (-)-BRX 005 hydrochloride; (-)-BRX 235 hydrochloride

Iroxanadine hydrochloride is a dual activator of p38 mitogen-activated protein kinase (MAPK) and heat shock proteins (HSPs). It exhibits vasculoprotective properties, making it a valuable tool for investigating mechanisms underlying atherosclerosis and various vascular diseases. This reagent is suitable for research applications focused on the modulation of inflammatory responses and cellular stress pathways.

Cat. No.

A37639

CAS No.

276690-62-1

Iroxanadine hydrobromide

Synonyms: (-)-BRX 005 hydrobromide; (-)-BRX 235 hydrobromide

Iroxanadine hydrobromide is a potent activator of p38 MAPK and HSP proteins. This compounds biological activity focuses on vasculoprotection, making it a valuable tool for investigating atherosclerosis and other vascular diseases. Its dual activation mechanisms provide insights into cellular stress responses and inflammation, making it relevant for research applications in cardiovascular health.

Cat. No.

A37640

CAS No.

276690-58-5

Iroxanadine

Synonyms: (-)-BRX 005; (-)-BRX 235

Iroxanadine is a dual activator of p38 MAPK and heat shock proteins (HSPs). It exhibits vasculoprotective properties, making it a valuable reagent for studying atherosclerosis and other vascular diseases. This compound can be utilized in research focusing on inflammatory responses and cardiovascular health, providing insights into the mechanisms underlying these conditions.

Cat. No.

A40663

CAS No.

153316-01-9

OVA-E1 peptide

OVA-E1 peptide is an activator of p38 MAPK, derived from the original SIINFEKL sequence (OVA 257-264). This peptide effectively stimulates both p38 and JNK signaling pathways in both mutant and wild-type thymocytes. It serves as a valuable tool for studying MAPK pathways and their roles in cellular responses such as inflammation and stress signaling in various research applications.