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MLK

MLK inhibitors block mixed-lineage kinases (MLKs), upstream kinases in cellular stress signaling. Like other mitogen-activated protein kinase kinase kinases (MAP3Ks), MLKs feed stress signals into the c-Jun N-terminal kinase (JNK) and p38 cascades. The family includes MLK1 to MLK4, dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK). MLK3 and DLK are studied in neuronal injury, neuroinflammation and axon degeneration. URMC-099 and MLK-IN-1 inhibit MLK3, GNE-8505 targets DLK, and (E)-2-Hexadecenal is listed as an MLK3 activator. The category also holds inhibitors of mixed lineage kinase domain-like protein (MLKL), a pseudokinase that executes necroptosis downstream of receptor-interacting protein kinase 3 (RIPK3). Necrosulfonamide, GW806742X and TC13172 belong to this second group of inhibitors.

1 Item

  • (E)-2-Hexadecenal
    Cat. No.
    A31257
    CAS No.
    22644-96-8

    (E)-2-Hexadecenal

    Synonyms: 16:1 Aldehyde; trans-2-Hexadecenal

    (E)-2-Hexadecenal is a selective activator of MLK3, known for inducing cytoskeletal remodeling that results in cellular rounding, detachment, and apoptosis in both human and mouse cells. By activating the MLK3 signaling pathway, it facilitates the phosphorylation of MKK4/7 and JNK, which in turn triggers the phosphorylation of downstream substrates such as c-Jun, alongside processes like cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. This compound is valuable for research into sphingolipid signaling pathways and related cellular mechanisms.

    In stock View Details
    0.5 mg
    $115.00
    1 mg
    $215.00
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