ML234 is a dual inhibitor targeting EZH2 and LSD1, exhibiting IC50 values of 0.09 μM and 0.12 μM, respectively. This compound demonstrates significant antiproliferative effects in prostate cancer cell lines, including LNCAP, PC3, and 22RV1. In vivo studies reveal that ML234 effectively suppresses tumor growth in the 22RV1 xenograft mouse model, making it a valuable tool for research focused on anticancer therapies in prostate cancer.
ML234 is a dual inhibitor targeting EZH2 and LSD1, exhibiting IC50 values of 0.09 μM and 0.12 μM, respectively. This compound demonstrates significant antiproliferative effects in prostate cancer cell lines, including LNCAP, PC3, and 22RV1. In vivo studies reveal that ML234 effectively suppresses tumor growth in the 22RV1 xenograft mouse model, making it a valuable tool for research focused on anticancer therapies in prostate cancer.
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