Mosnodenvir is an orally active pan-serotype inhibitor of the dengue virus (DENV), exhibiting EC50 values between 0.057 and 11 nM across four DENV serotypes. Its primary mechanism involves inhibiting the interaction between nonstructural proteins NS3 and NS4B, which is critical for preventing the replication of viral RNA. With demonstrated picomolar to nanomolar antiviral activity in vitro, Mosnodenvir also shows antiviral efficacy in murine and non-human primate models, making it a valuable tool for research into dengue virus treatment.
Mosnodenvir is an orally active pan-serotype inhibitor of the dengue virus (DENV), exhibiting EC50 values between 0.057 and 11 nM across four DENV serotypes. Its primary mechanism involves inhibiting the interaction between nonstructural proteins NS3 and NS4B, which is critical for preventing the replication of viral RNA. With demonstrated picomolar to nanomolar antiviral activity in vitro, Mosnodenvir also shows antiviral efficacy in murine and non-human primate models, making it a valuable tool for research into dengue virus treatment.
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