(R)-G12Di-7 is a covalent inhibitor specifically targeting K-Ras-G12D. This compound selectively binds to the K-Ras-G12D·GDP and K-Ras-G12D·GppNHp complexes, effectively labeling them. (R)-G12Di-7 demonstrates significant inhibitory activity against cancer cells harboring the G12D mutation, making it a valuable tool for research into K-Ras-related oncogenic signaling and potential therapeutic interventions.
(R)-G12Di-7 is a covalent inhibitor specifically targeting K-Ras-G12D. This compound selectively binds to the K-Ras-G12D·GDP and K-Ras-G12D·GppNHp complexes, effectively labeling them. (R)-G12Di-7 demonstrates significant inhibitory activity against cancer cells harboring the G12D mutation, making it a valuable tool for research into K-Ras-related oncogenic signaling and potential therapeutic interventions.
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