MS8511 hydrochloride is a selective irreversible inhibitor of G9a and GLP, targeting cysteine residues within the substrate binding site. It exhibits IC50 values of 100 nM for G9a and 140 nM for GLP, with Kd values of 44 nM and 46 nM, respectively. MS8511 hydrochloride effectively reduces cellular H3K9me2 levels and enhances antiproliferative activity. This compound is applicable in cancer research, particularly in studies involving brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as in investigations of neurodegenerative diseases such as Alzheimer’s disease and genetic disorders like Prader−Willi syndrome.
MS8511 hydrochloride is a selective irreversible inhibitor of G9a and GLP, targeting cysteine residues within the substrate binding site. It exhibits IC50 values of 100 nM for G9a and 140 nM for GLP, with Kd values of 44 nM and 46 nM, respectively. MS8511 hydrochloride effectively reduces cellular H3K9me2 levels and enhances antiproliferative activity. This compound is applicable in cancer research, particularly in studies involving brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as in investigations of neurodegenerative diseases such as Alzheimer’s disease and genetic disorders like Prader−Willi syndrome.
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