AChE

Cat. No.

A29362

CAS No.

252264-92-9

T 82

T 82 is a potent 5-HT3 receptor antagonist that also functions as an acetylcholinesterase (AChE) inhibitor. This compound exhibits significant biological activity relevant for modulating neurotransmitter signaling in the central nervous system. T 82 is primarily utilized in research related to neurodegenerative diseases, including Alzheimer's Disease, making it a valuable tool in understanding the pathophysiology and treatment approaches for related conditions.

Cat. No.

A34037

CAS No.

14587-50-9

Difeterol

Difeterol is an antihistamine agent that functions primarily as a histamine-1 receptor antagonist. It also inhibits butyrylcholinesterase (BChE), making it a valuable tool for studying cholinergic pathways. This compound is particularly relevant for research related to Alzheimer's disease, where modulation of histamine and cholinergic systems may provide insights into therapeutic strategies.

Cat. No.

A34117

CAS No.

2756368-79-1

AChE/BChE-IN-21

AChE/BChE-IN-21 is a histamine H3 receptor antagonist that also functions as a calcium channel blocker and acetylcholinesterase inhibitor. This compound demonstrates neuroprotective properties against oxidative stress induced by H2O2 and amyloid-beta peptide Aβ1-40. Additionally, AChE/BChE-IN-21 has been shown to improve cognitive function in mouse models of Alzheimer's disease, making it a valuable tool for research into neurodegenerative disorders.

Cat. No.

A34122

CAS No.

2970985-05-6

H3R antagonist 2

H3R Antagonist 2 is a selective antagonist of the histamine H3 receptor (H3R) with a Ki value of 170 nM for human H3R. This compound demonstrates inhibitory activity against acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B), with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. Additionally, H3R Antagonist 2 exhibits promising anti-neuropathic pain and memory-enhancing effects, effectively crossing the blood-brain barrier (BBB). This makes it a valuable tool for research in neuropharmacology and cognitive enhancement studies.

Cat. No.

A44489

CAS No.

15585-42-9

Resorufin butyrate

Resorufin butyrate is a fluorogenic substrate primarily utilized for the detection of triglyceride lipases and cholinesterase. With excitation at 570 nm and emission at 580 nm, this compound facilitates sensitive fluorescence-based assays. It is particularly valuable in biochemical studies focusing on lipid metabolism and enzyme activity.

Cat. No.

A49540

CAS No.

122898-67-3

Itopride

Synonyms: HSR803 free base

Itopride is a potent dopamine D2 receptor antagonist and an acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its dual mechanisms of action, promoting both antidopaminergic and anti-acetylcholinesterase effects. This compound is primarily utilized in research related to gastrointestinal disorders, particularly gastroesophageal reflux disease (GERD), offering insights into prokinetic therapies.

Cat. No.

A61298

CAS No.

361979-40-0

PCS1055 dihydrochloride

PCS1055 dihydrochloride is a selective and competitive antagonist of the muscarinic M4 receptor, with an IC50 value of 18.1 nM and a Kd of 5.72 nM. This compound effectively inhibits the binding of the radioligand [3H]-NMS to the M4 receptor, displaying a Ki of 6.5 nM. PCS1055 dihydrochloride demonstrates over 100-fold selectivity against M1, M3, and M5 receptors, and 30-fold selectivity at the M2 receptor. Additionally, it serves as a potent acetylcholinesterase inhibitor, with IC50 values of 22 nM and 120 nM for electric eel and human AChE, respectively, highlighting its potential for various neurological research applications.

Cat. No.

A61315

CAS No.

357173-55-8

PCS1055

PCS1055 is a selective competitive antagonist of the muscarinic M4 receptor, exhibiting an IC50 of 18.1 nM and a Kd of 5.72 nM. It effectively inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. Additionally, PCS1055 demonstrates inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 22 nM for electric eel AChE and 120 nM for human AChE. This compound is valuable for research focused on muscarinic receptor signaling and cholinergic modulation.

Cat. No.

A61461

CAS No.

153-76-4

Gallamine

Gallamine is a selective allosteric antagonist of the muscarinic M2 acetylcholine receptor, exhibiting an EC50 value of 130 nM in promoting the dissociation of [3H]NMS from porcine muscarinic M2 receptors. Additionally, it serves as an acetylcholinesterase inhibitor with varying IC50 values against different isoforms: 1070 μM for EeAChE, 1480 μM for hAChE, and 235 μM for hBChE. Gallamine is known to elevate levels of free norepinephrine and is utilized in research exploring muscle relaxation and pharmacological modulation of cholinergic signaling.

Cat. No.

A66199

CAS No.

215036-81-0

Phenchlobenpyrrone

Phenchlobenpyrrone is a selective neuronal calcium antagonist that effectively crosses the blood-brain barrier. This compound demonstrates the capability to mildly inhibit acetylcholinesterase (AChE) activity, along with inhibiting amyloid-beta (Aβ) aggregation and promoting the clearance of Aβ oligomers. Additionally, Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. This agent is valuable for research applications focused on Alzheimer's disease and related neurodegenerative conditions.

Cat. No.

A74063

CAS No.

79606-45-4

4-Chloro-N,N-diisopropylbenzamide

4-Chloro-N,N-diisopropylbenzamide is an amide with significant relevance as a substrate for cytochrome P450 enzymes in vivo and for acetylcholinesterase in vitro. This compound plays a crucial role in metabolic studies, enabling the investigation of enzyme kinetics and substrate specificity. Its application extends to research focused on drug metabolism and neuropharmacology.

Cat. No.

A78529

CAS No.

132567-18-1

Ac-IEAR-pNA

Ac-IEAR-pNA is a chromogenic substrate specifically designed for the quantification of endotoxin levels. It serves as a selective substrate for human butyrylcholinesterase (HuBChE), resulting in the cleavage that releases p-nitroaniline, a measurable product. This compound is widely used in research applications focused on endotoxin detection and related studies in immunology and toxicology.

Cat. No.

A78532

CAS No.

2921-88-2

Chlorpyrifos

Chlorpyrifos is a muscarinic antagonist and neurotoxic insecticide classified as a thionite ester. This compound acts primarily as an acetylcholinesterase (AChE) inhibitor, disrupting neurological function in various organisms, including insects and mammals. Research applications of Chlorpyrifos include investigations into neurodevelopmental effects, synaptic transmission alterations, and associated toxicological studies.

Cat. No.

A78548

CAS No.

9001-08-5

Cholinesterase, Horse serum

Synonyms: EC 3.1.1.8; BCHE; Horse serum

Cholinesterase, Horse serum is a catalytic enzyme comprising acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). These enzymes facilitate the hydrolysis of various substrates, including the hydrolysis of 6-monoacetylmorphine (6-MAM) to morphine. This reagent is valuable in biochemical research, particularly in studies involving neurotransmitter metabolism and the pharmacokinetics of opioid compounds.

Cat. No.

A78564

CAS No.

830-81-9

1-Naphthyl acetate

1-Naphthyl acetate serves as a chromogenic substrate specifically for the detection of acetylcholinesterase (AChE) activity in erythrocytes. This compound is particularly valuable in research related to organophosphorus pesticide poisoning, enabling the assessment of enzymatic activity and its inhibition. Its colorimetric properties facilitate quantitative analysis in various biochemical studies.

Cat. No.

A78859

CAS No.

125-51-9

Pipenzolate bromide

Pipenzolate bromide is a muscarinic receptor antagonist that functions by inhibiting cholinesterase (ChE) activity, thereby preventing the binding of acetylcholine to its receptors. This compound exhibits significant anticholinergic properties, making it valuable in pharmacological research related to disorders such as motion sickness, asthma, and gastrointestinal motility. Pipenzolate bromide serves as a useful reagent in studies aimed at understanding the modulation of cholinergic signaling pathways.

Cat. No.

A86583

CAS No.

1866-15-5

Acetylthiocholine iodide

Synonyms: S-Acetylthiocholine iodide; ATCh iodide

Acetylthiocholine iodide serves as a substrate for enzymes such as cholinesterase, enabling the quantification of enzyme activity levels. This compound is utilized in various biochemical assays and has applications in medical research, particularly in neuroscience and organ physiology studies. Its role in enzyme activity determination makes it a valuable reagent for investigating cholinergic signaling pathways.

Cat. No.

A86809

CAS No.

1866-16-6

S-n-Butyrylthiocholine iodide

S-n-Butyrylthiocholine iodide functions as a substrate for butyrylcholinesterase (BChE). This chemical reagent is primarily utilized in biochemical assays to study enzyme activity and kinetics, providing valuable insights into the role of BChE in various physiological processes. Its application is essential for in vitro enzymatic experiments, contributing to the understanding of cholinergic signaling and related biochemical pathways.

Cat. No.

A87572

CAS No.

2963-78-2

Butyrylcholine chloride

Butyrylcholine chloride is a biochemical assay reagent that serves as a substrate for butyrylcholinesterase. This compound is essential for investigating cholinergic signaling pathways and the enzymatic activity associated with neurotransmitter regulation. It is widely utilized in research applications focusing on neurobiology, pharmacology, and toxicology, facilitating studies on enzyme kinetics and cholinergic receptor interactions.

Cat. No.

A88055

CAS No.

2494-56-6

Butyrylcholine iodide

Butyrylcholine iodide is a biochemical assay reagent that functions as a substrate for cholinesterases, facilitating the study of enzyme activity. Its hydrolysis produces butyric acid and choline, making it valuable for exploring cholinergic signaling pathways and neurochemical research. This compound is widely used in assays to evaluate the effects of inhibitors or activators on cholinesterase activity, contributing to advancements in pharmacology and neurobiology.

Cat. No.

A88249

CAS No.

6050-81-3

Acetylthiocholine chloride

Acetylthiocholine chloride acts as a biochemical assay reagent primarily utilized for the detection of acetylcholinesterase activity. This compound is commonly employed in various research applications, including studies on neurophysiology and the assessment of cholinergic signaling. Its ability to serve as a substrate for enzymatic reactions makes it valuable in the exploration of neurotransmitter dynamics and related pharmacological investigations.

Cat. No.

A92448

CAS No.

10561-14-5

Benzoylthiocholine iodide

Benzoylthiocholine iodide is a biochemical assay reagent that serves as a substrate for cholinesterase enzymes. It is predominantly used in enzyme activity assays to study physiological and pathological processes involving cholinergic signaling. The compound's ability to generate measurable products upon enzymatic hydrolysis makes it valuable for probing enzyme kinetics and screening potential enzyme inhibitors in research applications.