AChE

Cat. No.

A17526

CAS No.

94-63-3

Pralidoxime Iodide

Synonyms: NSC-7760

Pralidoxime iodide is a Cholinesterase Reactivator.

Cat. No.

A78719

CAS No.

2417117-84-9

AChE/Nrf2 modulator 1

AChE/Nrf2 Modulator 1 is an orally active compound that targets both acetylcholinesterase (AChE) and the nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits significant Nrf2 inductive activity along with potent AChE inhibitory effects, presenting IC50 values of 0.07 μM for eel AChE and 0.38 μM for human AChE. This compound is primarily utilized in research focused on Alzheimer's disease, providing insights into neuroprotective mechanisms and cholinergic system modulation.

Cat. No.

A78849

CAS No.

133920-70-4

FK960

FK960 is a cholinesterase activator with potential applications in anti-dementia therapy. It enhances cholinergic neurotransmission, effectively reversing the reduction in cerebral blood flow (rCBF) induced by sensory stimulation. In macaque studies, FK960 has demonstrated the ability to restore rCBF responses that were eliminated by treatment with physostigmine, lasting for up to one hour. Notably, FK960 does not restore rCBF responses affected by NMDA modulators, suggesting a targeted mechanism independent of non-glutamatergic pathways.

Cat. No.

A78863

CAS No.

119229-64-0

HP 184

HP 184 is an acetylcholine release stimulator, functioning as a cholinesterase (ChE) activator. This compound enhances synaptic transmission by promoting the release of acetylcholine, making it valuable for studies in neurobiology and neuromuscular disorders. Additionally, the compound's ADME properties can be modified by substituting hydrogen with deuterium, allowing for further exploration of its pharmacokinetics and pharmacodynamics in research applications.

Cat. No.

A79609

CAS No.

26172-55-4

Methylchloroisothiazolinone

Methylchloroisothiazolinone is a potent NF-κB activator known for its pro-inflammatory properties. It induces the expression of pro-inflammatory cytokines, including IL-1β, TNF-α, and IL-6, through the activation of the NF-κB signaling pathway and upregulation of TLR4. This compound is utilized in research focusing on allergic contact dermatitis and immunotoxicity mechanisms. Additionally, Methylchloroisothiazolinone demonstrates neurotoxic effects and has been shown to impair cholinesterase activity, leading to increased oxidative stress and detrimental impacts on aquatic organisms, specifically Mediterranean mussels.