CaMK

Cat. No.

A31893

CAS No.

41787-69-3

Junicedric acid

Junicedric acid is a diterpenoid compound that functions as an activator of Protein Kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII). This compound exhibits neuroprotective properties by elevating intracellular calcium levels in hippocampal neurons, thereby mitigating amyloid-β oligomer-induced synaptic protein loss, apoptosis, and inhibition of long-term potentiation (LTP). Junicedric acid serves as a valuable tool for investigating the pathological mechanisms underlying neurodegenerative diseases, including Alzheimer’s disease.

Cat. No.

A39414

CAS No.

129198-88-5

Autocamtide 2

Synonyms: Autocamtide II

Autocamtide 2 is a selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII). This reagent is primarily utilized in assays to measure CaMKII activity, providing valuable insights into cellular signaling pathways influenced by calcium. Its specificity ensures reliable results in research applications involving calcium-dependent processes.

Cat. No.

A39538

CAS No.

108334-68-5

Syntide 2

Syntide 2 is a substrate peptide for calcium/calmodulin-dependent protein kinase II (CaMKII) that demonstrates selective inhibition of the gibberellin (GA) signaling pathway. By targeting this pathway, Syntide 2 facilitates the investigation of mechanisms underlying plant hormone responses while preserving the activity of other regulatory events, such as those mediated by abscisic acid. This reagent is valuable for studies related to cellular signaling and hormone regulation in plant biology.

Cat. No.

A61890

CAS No.

1030759-58-0

FO-4-15

FO-4-15 is an mGluR1/CaMKIIα activator that demonstrates neuroprotective effects against oxidative stress, specifically H2O2, in human neuroblastoma SH-SY5Y cells. This compound enhances cognitive function in mouse models of Alzheimer’s disease by engaging the mGluR1/CaMKIIα signaling pathway, leading to a reduction in amyloid-beta accumulation, hyperphosphorylated Tau, and synaptic damage. It serves as a valuable tool for investigating mechanisms of neuroprotection and cognitive impairment in neurodegenerative diseases.

Cat. No.

A78515

CAS No.

82801-68-1

Calmodulin Dependent Protein Kinase Substrate

Calmodulin Dependent Protein Kinase Substrate is a synthetic peptide designed as a substrate for calmodulin-dependent protein kinases (CaMKs) that are activated by calcium ions (Ca2+) and calmodulin (CaM). This substrate is crucial for studying the phosphorylation activity of CaMKs and aids in understanding their role in various cellular signaling pathways. It is relevant for research applications in signal transduction and regulatory mechanisms in calcium signaling.

Cat. No.

A78517

CAS No.

142828-10-2

Autocamtide-3

Autocamtide-3 is a selective substrate for Ca2+/calmodulin-dependent kinase II (CaMKII), characterized by its 13-amino-acid sequence that includes the phosphorylatable residue Thr287. This peptide serves as a valuable tool for studying the activation and regulation of CaMKII in various biological contexts. Its application in research encompasses investigations into calcium signaling, neuronal function, and cardiac physiology.

Cat. No.

A78523

CAS No.

123067-01-6

Calmodulin Dependent Protein Kinase Substrate Analog

Calmodulin Dependent Protein Kinase Substrate Analog is a synthetic peptide designed as a substrate for calmodulin-dependent protein kinases (CaMK). As a Ca2+- and calmodulin-dependent substrate, it facilitates the study of CaMK activity and regulation in cellular signaling pathways. This analog is valuable for investigating phosphorylation processes and the role of CaMK in various biological systems, making it a useful tool in biochemical and pharmacological research.