Dopamine Transporter

Cat. No.

A45832

CAS No.

99295-33-7

SKF-83566

SKF-83566 is a selective antagonist of the D1-like dopamine receptors, specifically targeting the dopamine D1 and D5 receptors. This compound exhibits potent inhibition of the dopamine transporter (DAT) with an IC50 of 5.7 μM, and shows competitive antagonism at the vascular 5-HT2 receptor. In addition, SKF-83566 selectively inhibits adenylyl cyclase 2 (AC2) over AC1 and AC5, making it relevant for research into neurological disorders such as Parkinson's disease and studies focused on alleviating nicotine cravings.

Cat. No.

A46025

CAS No.

108179-91-5

SKF-83566 hydrobromide

SKF-83566 hydrobromide is a selective antagonist of the D1-like dopamine receptors, exhibiting high blood-brain barrier permeability and oral bioavailability. This compound functions as a competitive inhibitor of the dopamine transporter (DAT), with an IC50 of 5.7 μM, and demonstrates a weaker antagonistic effect on the vascular 5-HT2 receptor (Ki=11 nM). Additionally, SKF-83566 selectively inhibits adenylyl cyclase 2 (AC2) over AC1 and AC5, making it a valuable tool for studying Parkinson's disease and nicotine dependence.

Cat. No.

A78907

CAS No.

75859-04-0

Rimcazole

Synonyms: BW 234U

Rimcazole is a potent antipsychotic agent primarily known for its role as a competitive antagonist of sigma receptors. It demonstrates significant efficacy in modulating dopaminergic pathways, making it valuable for research related to acute schizophrenic disorders. This compound aids in the exploration of schizophrenia mechanisms and potential therapeutic interventions.