AChE

Cat. No.

A29362

CAS No.

252264-92-9

T 82

T 82 is a potent 5-HT3 receptor antagonist that also functions as an acetylcholinesterase (AChE) inhibitor. This compound exhibits significant biological activity relevant for modulating neurotransmitter signaling in the central nervous system. T 82 is primarily utilized in research related to neurodegenerative diseases, including Alzheimer's Disease, making it a valuable tool in understanding the pathophysiology and treatment approaches for related conditions.

Cat. No.

A34037

CAS No.

14587-50-9

Difeterol

Difeterol is an antihistamine agent that functions primarily as a histamine-1 receptor antagonist. It also inhibits butyrylcholinesterase (BChE), making it a valuable tool for studying cholinergic pathways. This compound is particularly relevant for research related to Alzheimer's disease, where modulation of histamine and cholinergic systems may provide insights into therapeutic strategies.

Cat. No.

A34117

CAS No.

2756368-79-1

AChE/BChE-IN-21

AChE/BChE-IN-21 is a histamine H3 receptor antagonist that also functions as a calcium channel blocker and acetylcholinesterase inhibitor. This compound demonstrates neuroprotective properties against oxidative stress induced by H2O2 and amyloid-beta peptide Aβ1-40. Additionally, AChE/BChE-IN-21 has been shown to improve cognitive function in mouse models of Alzheimer's disease, making it a valuable tool for research into neurodegenerative disorders.

Cat. No.

A34122

CAS No.

2970985-05-6

H3R antagonist 2

H3R Antagonist 2 is a selective antagonist of the histamine H3 receptor (H3R) with a Ki value of 170 nM for human H3R. This compound demonstrates inhibitory activity against acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B), with IC50 values of 180 nM, 880 nM, and 775 nM, respectively. Additionally, H3R Antagonist 2 exhibits promising anti-neuropathic pain and memory-enhancing effects, effectively crossing the blood-brain barrier (BBB). This makes it a valuable tool for research in neuropharmacology and cognitive enhancement studies.

Cat. No.

A49540

CAS No.

122898-67-3

Itopride

Synonyms: HSR803 free base

Itopride is a potent dopamine D2 receptor antagonist and an acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its dual mechanisms of action, promoting both antidopaminergic and anti-acetylcholinesterase effects. This compound is primarily utilized in research related to gastrointestinal disorders, particularly gastroesophageal reflux disease (GERD), offering insights into prokinetic therapies.

Cat. No.

A61298

CAS No.

361979-40-0

PCS1055 dihydrochloride

PCS1055 dihydrochloride is a selective and competitive antagonist of the muscarinic M4 receptor, with an IC50 value of 18.1 nM and a Kd of 5.72 nM. This compound effectively inhibits the binding of the radioligand [3H]-NMS to the M4 receptor, displaying a Ki of 6.5 nM. PCS1055 dihydrochloride demonstrates over 100-fold selectivity against M1, M3, and M5 receptors, and 30-fold selectivity at the M2 receptor. Additionally, it serves as a potent acetylcholinesterase inhibitor, with IC50 values of 22 nM and 120 nM for electric eel and human AChE, respectively, highlighting its potential for various neurological research applications.

Cat. No.

A61315

CAS No.

357173-55-8

PCS1055

PCS1055 is a selective competitive antagonist of the muscarinic M4 receptor, exhibiting an IC50 of 18.1 nM and a Kd of 5.72 nM. It effectively inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of 6.5 nM. Additionally, PCS1055 demonstrates inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 22 nM for electric eel AChE and 120 nM for human AChE. This compound is valuable for research focused on muscarinic receptor signaling and cholinergic modulation.

Cat. No.

A61461

CAS No.

153-76-4

Gallamine

Gallamine is a selective allosteric antagonist of the muscarinic M2 acetylcholine receptor, exhibiting an EC50 value of 130 nM in promoting the dissociation of [3H]NMS from porcine muscarinic M2 receptors. Additionally, it serves as an acetylcholinesterase inhibitor with varying IC50 values against different isoforms: 1070 μM for EeAChE, 1480 μM for hAChE, and 235 μM for hBChE. Gallamine is known to elevate levels of free norepinephrine and is utilized in research exploring muscle relaxation and pharmacological modulation of cholinergic signaling.

Cat. No.

A66199

CAS No.

215036-81-0

Phenchlobenpyrrone

Phenchlobenpyrrone is a selective neuronal calcium antagonist that effectively crosses the blood-brain barrier. This compound demonstrates the capability to mildly inhibit acetylcholinesterase (AChE) activity, along with inhibiting amyloid-beta (Aβ) aggregation and promoting the clearance of Aβ oligomers. Additionally, Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. This agent is valuable for research applications focused on Alzheimer's disease and related neurodegenerative conditions.

Cat. No.

A78532

CAS No.

2921-88-2

Chlorpyrifos

Chlorpyrifos is a muscarinic antagonist and neurotoxic insecticide classified as a thionite ester. This compound acts primarily as an acetylcholinesterase (AChE) inhibitor, disrupting neurological function in various organisms, including insects and mammals. Research applications of Chlorpyrifos include investigations into neurodevelopmental effects, synaptic transmission alterations, and associated toxicological studies.

Cat. No.

A78859

CAS No.

125-51-9

Pipenzolate bromide

Pipenzolate bromide is a muscarinic receptor antagonist that functions by inhibiting cholinesterase (ChE) activity, thereby preventing the binding of acetylcholine to its receptors. This compound exhibits significant anticholinergic properties, making it valuable in pharmacological research related to disorders such as motion sickness, asthma, and gastrointestinal motility. Pipenzolate bromide serves as a useful reagent in studies aimed at understanding the modulation of cholinergic signaling pathways.