NMDA Receptors

Cat. No.

A13144

CAS No.

169274-78-6

Ro 25-6981

Ro 25-6981 is a high-affinity, potent and selective blocker of N-methyl- D-aspartate (NMDA) receptors.

Cat. No.

A13576

CAS No.

117928-94-6

Rapastinel (GLYX-13)

Synonyms: GLYX 13

GLYX-13 is a selective weak partial agonist of the glycine site of the NMDA receptor which is under development by Naurex as adjunctive therapy for treatment-resistant depression.

Cat. No.

A16083

CAS No.

1312991-76-6

RO 25-6981 maleate

Synonyms: Ro25-6981

Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 uM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively.

Cat. No.

A19339

CAS No.

153322-05-5

Lanicemine

Synonyms: AZD6765

Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a binding (Ki) of 0.56-2.1 μM.

Cat. No.

A20075

CAS No.

1421866-48-9

Apimostinel

Synonyms: NRX-1074; AGN-241660

Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist.

Cat. No.

A67069

CAS No.

1118-68-9

N,N-Dimethylglycine

Synonyms: Dimethylglycine; DMG; N-Methylsarcosine

N,N-Dimethylglycine is a natural N-methylated glycine that serves as a partial agonist at the N-methyl-D-aspartate receptor (NMDAR) glycine site. It functions as a methyl donor, enhancing immune response and exhibiting antioxidant properties to mitigate oxidative stress by scavenging free radicals. Additionally, N,N-Dimethylglycine has demonstrated antidepressant-like effects and surfactant activity, making it valuable for various research applications in neuropharmacology and immunology.

Cat. No.

A67102

CAS No.

46026-75-9

cis-Piperidine-2,3-dicarboxylic acid

Cis-Piperidine-2,3-dicarboxylic acid primarily targets NMDA receptors and acts as a partial agonist. This compound is known for its ability to block general excitatory synaptic transmission by interfering with NMDA, AMPA, and kainate ionotropic receptors. Cis-Piperidine-2,3-dicarboxylic acid is valuable for research applications related to neuropharmacology and the study of synaptic plasticity.

Cat. No.

A67104

CAS No.

2151842-64-5

Zelquistinel

Synonyms: AGN-241751; GATE-251

Zelquistinel (AGN-241751) is a potent orally active partial agonist of the N-methyl-D-aspartate (NMDA) receptor. It has demonstrated significant biological activity relevant to the research of neuropsychiatric conditions, including depression and anxiety. Zelquistinel serves as a valuable tool for studying the pharmacological mechanisms underlying these disorders and evaluating potential therapeutic interventions.

Cat. No.

A67181

CAS No.

123931-04-4

(R)-(+)-HA-966

Synonyms: (+)-HA-966

(R)-(+)-HA-966 functions as a partial agonist/antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. This compound selectively inhibits the activation of the mesolimbic dopamine system induced by amphetamine, making it relevant for studying addiction and dopamine-related disorders. Its ability to traverse the blood-brain barrier suggests potential applications in addressing conditions such as neuropathic and acute pain.

Cat. No.

A67219

CAS No.

3227-01-8

N-Phthaloylglutamic acid

N-Phthaloylglutamic acid functions as a partial agonist of the NMDA receptor, specifically targeting the glutamate binding site with an affinity characterized by a Ki of 13 μM. Its biological activity contributes to the modulation of excitatory neurotransmission and may serve as a valuable tool in neuropharmacological research. This reagent is useful for studies investigating NMDA receptor dynamics and related neurological processes.

Cat. No.

A67250

CAS No.

117928-93-5

NT 13

Synonyms: TPPT

NT 13 (TPPT) is a tetrapeptide with the amino acid sequence L-threonyl-L-prolyl-L-prolyl-L-threonine amide, acting as a partial agonist of the N-methyl-D-aspartate receptor (NMDAR). This compound is utilized in research pertaining to depression, anxiety, and related neuropsychiatric conditions. Its ability to modulate glutamatergic signaling provides valuable insights into the underlying mechanisms of these disorders, making it a useful tool for pharmacological studies.

Cat. No.

A67269

CAS No.

209969-60-8

Ensaculin

Synonyms: KA-672 hydrochloride; Anseculin hydrochloride

Ensaculin is an NMDA receptor channel blocker that exhibits neuroprotective properties in models of NMDA toxicity. This compound promotes neuronal growth in primary cultures of rat brain cells, suggesting its potential for application in neurodegenerative research. Furthermore, Ensaculin holds promise as a candidate for anti-dementia therapies by modulating various neurotransmitter systems.

Cat. No.

A67366

CAS No.

76991-05-4

NMDAR blocker 1

NMDAR blocker 1 is an NMDA receptor channel blocker with an IC50 of 5.0 μM, characterized by rapid on-off kinetics and strong voltage dependence, without competing with glutamate or glycine. This reagent effectively prevents glutamate/NMDA-induced intracellular Ca2+ overload and modulates the glutamate-nitric oxide-cGMP signaling pathway. NMDAR blocker 1 has been demonstrated to impede excitotoxic neurodegeneration in cultured cerebellar and hippocampal neurons, as well as mitigate excitotoxic effects in a mouse model of hyperammonemia-induced toxicity. It serves as a valuable tool for research into neurodegenerative diseases.

Cat. No.

A67406

CAS No.

217176-91-5

Caged MK801

Caged MK801 is a selective, non-competitive, irreversible blocker of the NMDA receptor, targeting the open-channel state. It is designed to release MK801 upon photolysis, providing a tool for precise temporal control in neuronal studies. This compound is compatible with neuropharmacological applications, enabling exploration of synaptic plasticity and neurodegeneration mechanisms.