Transthyretin (TTR)

Cat. No.

A14111

CAS No.

594839-88-0

Tafamidis (Fx1006A)

Synonyms: Fx-1006A

Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

Cat. No.

A18045

CAS No.

951395-08-7

Tafamidis meglumine

Synonyms: Fx-1006A

Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM.

Cat. No.

A79390

CAS No.

1446711-81-4

Acoramidis

Synonyms: AG10

Acoramidis, also known as AG10, is a selective kinetic stabilizer that targets wild-type and V122I transthyretin (TTR). It is utilized in research focused on transthyretin amyloidosis, facilitating the understanding of its molecular mechanisms and potential therapeutic strategies. Through its stabilization of TTR, Acoramidis contributes valuable insights into the treatment of amyloid-related diseases.

Cat. No.

A79392

CAS No.

2242751-53-5

Acoramidis hydrochloride

Synonyms: AG10 hydrochloride

Acoramidis hydrochloride is a selective kinetic stabilizer of wild-type and V122I transthyretin (TTR). This compound is actively researched for its potential to inhibit the formation of amyloid fibrils associated with transthyretin amyloidosis. Its application in preclinical and clinical studies aims to further understand TTR's role in disease pathways and to develop effective therapeutic strategies.

Cat. No.

A79395

CAS No.

2778162-15-3

TTR stabilizer 1

TTR Stabilizer 1 is a potent stabilizer of Transthyretin (TTR) with an EC50 value of 0.031 μM. This compound enhances TTR stability, making it an important tool for research into amyloid diseases associated with TTR misfolding. Its ability to modulate TTR functional integrity offers significant potential for studies focused on therapeutic interventions in related pathologies.

Cat. No.

A79400

CAS No.

881290-53-5

TTR stabilizer L6

TTR Stabilizer L6 is a specific compound that binds to the T4 binding pocket of transthyretin (TTR), effectively preventing its dissociation into monomers. This stabilization is crucial for maintaining TTR's functional integrity, making L6 a valuable tool in the study of familial amyloid polyneuropathy. Its ability to modulate TTR behavior positions it as a promising candidate for research focused on amyloid-related diseases.