We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

IκK/IκB

IκK/IκB inhibitors act on the IκB kinase (IKK) complex, which frees nuclear factor kappa B (NF-κB) from IκB. In 1997 a cytokine-responsive IKK was purified, and the complex was shown to contain two catalytic subunits, IKKα and IKKβ. The kinases phosphorylate IκBα, which marks this inhibitor for degradation and frees NF-κB dimers to enter the nucleus. BMS-345541 HCl, described in 2003, binds an allosteric site on IKK and blocks NF-κB-dependent transcription. IKK-16 inhibits IKKβ and the IKK complex, while IMD 0354 and Bay 65-1942 HCl act mainly on IKKβ. BAY 11-7085 is used to block IκBα phosphorylation in cells. BX-795 targets the related TANK-binding kinase 1 (TBK1) and IKKε along with 3-phosphoinositide-dependent protein kinase 1 (PDK1).

3 Items

  • Bardoxolone methyl
    Cat. No.
    A11323
    CAS No.
    218600-53-4

    Bardoxolone methyl (RTA 402)

    Synonyms: NSC 713200; CDDO-methyl ester; RTA 402

    Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

    In stock View Details
    5 mg
    $25.00
    10 mg
    $30.00
    All 8 sizes
  • WS3
    Cat. No.
    A12952
    CAS No.
    1421227-52-2

    WS3

    WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

    In stock View Details
    5 mg
    $35.00
    10 mg
    $60.00
    All 6 sizes
  • WS6
    Cat. No.
    A12953
    CAS No.
    1421227-53-3

    WS6

    WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $40.00
    All 7 sizes

3 Items

Added to your cart

View Cart Checkout

    Loading...