Nur77 agonist-1 is a selective agonist targeting the Nur77 receptor, promoting ferroptosis through the upregulation of Nur77 protein expression. This compound significantly elevates levels of reactive oxygen species (ROS) and lipid peroxidation while diminishing GPX4 protein expression. With a binding affinity of 13.80 μM to the ligand binding domain of Nur77, Nur77 agonist-1 demonstrates potent antiproliferative effects against various breast cancer cell lines (IC50: 2.15-3.26 μM) while exhibiting low toxicity to normal cells. It is a valuable tool for research focused on breast cancer therapies.
Nur77 agonist-1 is a selective agonist targeting the Nur77 receptor, promoting ferroptosis through the upregulation of Nur77 protein expression. This compound significantly elevates levels of reactive oxygen species (ROS) and lipid peroxidation while diminishing GPX4 protein expression. With a binding affinity of 13.80 μM to the ligand binding domain of Nur77, Nur77 agonist-1 demonstrates potent antiproliferative effects against various breast cancer cell lines (IC50: 2.15-3.26 μM) while exhibiting low toxicity to normal cells. It is a valuable tool for research focused on breast cancer therapies.
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