4-PQBH is a potent binder of Nur77, exhibiting a dissociation constant (KD) of 1.17 μM. This compound significantly induces caspase-independent cytoplasmic vacuolization and paraptosis through the mediation of endoplasmic reticulum (ER) stress and autophagy pathways. 4-PQBH serves as a valuable tool for cancer research, particularly in the study of cell death mechanisms and neurodegenerative disorders.
4-PQBH is a potent binder of Nur77, exhibiting a dissociation constant (KD) of 1.17 μM. This compound significantly induces caspase-independent cytoplasmic vacuolization and paraptosis through the mediation of endoplasmic reticulum (ER) stress and autophagy pathways. 4-PQBH serves as a valuable tool for cancer research, particularly in the study of cell death mechanisms and neurodegenerative disorders.
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