Nur77 modulator 3 is an effective modulator of Nur77, targeting the regulation of hepatic stellate cell (HSC) activation. This compound induces Nur77 expression, leading to decreased ECM deposition and enhanced autophagic flux that is dependent on Nur77. Additionally, it significantly inhibits the mTORC1 signaling pathway, resulting in reduced inflammation and amelioration of hepatic fibrosis in vivo. Nur77 modulator 3 is particularly useful for studies related to liver pathology and fibrosis research.
Nur77 modulator 3 is an effective modulator of Nur77, targeting the regulation of hepatic stellate cell (HSC) activation. This compound induces Nur77 expression, leading to decreased ECM deposition and enhanced autophagic flux that is dependent on Nur77. Additionally, it significantly inhibits the mTORC1 signaling pathway, resulting in reduced inflammation and amelioration of hepatic fibrosis in vivo. Nur77 modulator 3 is particularly useful for studies related to liver pathology and fibrosis research.
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