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Other Inhibitors groups bioactive small molecules whose targets fall outside the pathway categories of this catalogue. The compounds have not yet been assigned to target categories, so the range is broad and uneven. Streptozotocin, a glucosamine-nitrosourea compound used to induce experimental diabetes in rodents, sits beside the O-GlcNAcase inhibitor Thiamet G. Exherin is an N-cadherin antagonist, and AdipoRon is an agonist of adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2). Plant compounds such as the isoflavone daidzein are also included. Despite the category name, not every compound is an inhibitor, as the AdipoRon example shows. Compounds with a well-defined target are usually listed in the matching pathway or target category.
D-cycloserine is a partial agonist at the glycine receptor, and has been shown to have cognition-enhancing properties for models of Parkinsons disease in primates.
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.
Synonyms: Firefly Luciferin
D-Luciferin is a popular bioluminescent substrate of luciferase in the presence of ATP, used in luciferase-based bioluminescence imaging and cell-based high-throughput screening applications.
Synonyms: Tretazicar
CB1954 is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent.It can be activated by NAD(P)H quinone oxidoreductase 2.
Synonyms: CLZN
Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques.
RETF-4NA is a chymase substrate peptide that is cleaved more avidly by α2-macroglobulin-bound chymase than the free, unbound form.
Synonyms: p-Aminohippuric acid
4-Aminohippuric acid is a typical substrate of organic anion transport systems.
L-Lysine thioctate is a substrate of lipoamidase.
Synonyms: 2'-Deoxy-2'-fluoro-5-Methyluridine
2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2).
Velaresol, also known as BW12C or BW12C79, is a oxyhaemoglobin stabilizer.
