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Chelators & Bifunctional Chelators

Chelators and bifunctional chelators bind metal ions through several donor atoms of one molecule. The coordinating groups hold the ion in a ring structure, which lowers its free concentration and changes its redox behavior and availability. Calcium-selective chelators such as BAPTA buffer intracellular calcium in cell biology and electrophysiology experiments. Iron chelators form the largest group here and include HBED, deferitazole, VK-28 and CN128 hydrochloride, used in studies of iron metabolism and oxidative stress. Penicillamine and succimer bind copper, lead and other heavy metals through thiol and amine donors. Bifunctional chelators add a reactive group for coupling to peptides or proteins, as in DTPA-tetra (t-Bu ester), a protected form of diethylenetriaminepentaacetic acid (DTPA).

Cat. No.

A41633

CAS No.

306776-79-4

DOTA-GA(tBu)4

DOTA-GA(tBu)4 is a bifunctional prochelator designed to enhance the stability of radiometals bound to ligands. This compound significantly improves the biodistribution of radiolabeled second-generation Affibody molecules by increasing their net negative charge, which reduces hepatic uptake and enhances tumor-to-blood and tumor-to-liver ratios. DOTA-GA(tBu)4 is particularly relevant for research involving HER2-positive breast and gastrointestinal cancers, facilitating targeted imaging and therapeutic applications.

In stock View Details

10 mg

$25.00

25 mg

$45.00

All 4 sizes

Chelators & Bifunctional Chelators

DOTA-GA(tBu)4