Drug Impurity

Cat. No.

A34865

CAS No.

1788901-86-9

Lenvatinib N-oxide

Synonyms: Lenvatinib impurity 10

Lenvatinib N-oxide is a significant impurity of Lenvatinib, a multi-targeted tyrosine kinase inhibitor known for its oral bioactivity. This compound serves as an important reference standard in pharmacological studies, aiding the characterization and quality control of Lenvatinib. Researchers may utilize Lenvatinib N-oxide for analytical purposes to assess the purity and stability of Lenvatinib formulations in various biological research contexts.

Cat. No.

A42225

CAS No.

139755-91-2

Desethyl sildenafil

Synonyms: Sildenafil impurity C

Desethyl Sildenafil is an impurity of Sildenafil, primarily known as a potent phosphodiesterase type 5 (PDE5) inhibitor, with an IC50 value of 5.22 nM. It serves as an important reference standard in the analysis of Sildenafil formulations and is utilized in the investigation of PDE5 inhibition. Research applications include quality control and pharmacokinetic studies related to Sildenafil.

Cat. No.

A42402

CAS No.

108731-95-9

Ramipril diketopiperazine

Ramipril diketopiperazine is a chemical impurity associated with the ACE inhibitor Ramipril. It is important for analytical studies and quality control in pharmaceutical research, particularly in the evaluation of drug formulation and stability. The presence of this impurity can influence the pharmacokinetics and safety profile of Ramipril, making it crucial for researchers analyzing drug metabolism and efficacy.

Cat. No.

A42420

CAS No.

108736-10-3

Ramiprilat diketopiperazine

Synonyms: Ramipril diketopiperazine acid

Ramiprilat diketopiperazine, also known as Impurity K of Ramiprilat, serves as a significant impurity within the context of pharmaceutical research. Ramiprilat, an active metabolite of Ramipril, functions primarily as a potent angiotensin-converting enzyme (ACE) inhibitor. This compound is important for studying the effects and stability of Ramiprilat in various formulations and can be useful in analytical chemistry to ensure the purity of ACE inhibitors in development.

Cat. No.

A43506

CAS No.

1418133-47-7

Linagliptin methyldimer

Linagliptin methyldimer is a known impurity of Linagliptin, a potent Dipeptidyl Peptidase IV (DPP-IV) inhibitor that exhibits an IC50 of approximately 1 nM. This compound is utilized primarily in analytical studies to characterize and quantify impurities in Linagliptin formulations. Its presence and behavior are essential for understanding the purity and efficacy of DPP-IV-related therapies in diabetes research.

Cat. No.

A48294

CAS No.

2623-33-8

4-Acetamidophenyl acetate

Synonyms: Diacetamate

4-Acetamidophenyl acetate is identified as an impurity of Acetaminophen and serves as an intermediate in its synthesis. Acetaminophen is known for its selective inhibition of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM, along with notable activity as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). This reagent is valuable for research applications focused on analgesic and anti-inflammatory drug development.

Cat. No.

A50379

CAS No.

96497-73-3

Keto lovastatin

Keto lovastatin is an impurity of Lovastatin that acts as an HMG-CoA reductase inhibitor. This compound exhibits antibacterial activity and is primarily utilized for research related to cholesterol synthesis and metabolic pathways. It serves as a crucial reference material in studies focused on Lovastatin and its derivatives, enhancing understanding of their pharmacological profiles.

Cat. No.

A52035

CAS No.

1191921-01-3

Oseltamivir-acetate

Oseltamivir-acetate is an impurity associated with Oseltamivir, a well-known neuraminidase inhibitor utilized in the treatment and prevention of influenza A and B. This compound is valuable for research applications involving the analysis of Oseltamivir's purity and the study of its pharmacological properties in antiviral therapies. Understanding the presence of impurities like Oseltamivir-acetate can aid in the development of more effective influenza treatments and enhance the overall quality of the drug formulation.

Cat. No.

A54159

CAS No.

1023594-50-4

1,1-Dimethylethyl 4-(4-amino-3-pyridinyl)-1-piperazinecarboxylate

1,1-Dimethylethyl 4-(4-amino-3-pyridinyl)-1-piperazinecarboxylate is identified as an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound aids in the quality assessment of Palbociclib by providing insights into the synthesis and purification processes. Its analysis is crucial for ensuring the integrity and efficacy of CDK inhibition studies, primarily focusing on cell cycle regulation and cancer research applications.

Cat. No.

A54178

CAS No.

1245914-05-9

1,1-Dimethylethyl 4-(5-amino-3-pyridinyl)-1-piperazinecarboxylate

1,1-Dimethylethyl 4-(5-amino-3-pyridinyl)-1-piperazinecarboxylate is an identified impurity of Palbociclib, an orally administered selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6). Palbociclib demonstrates potent biological activity with IC50 values of 11 nM and 16 nM for CDK4 and CDK6, respectively. This reagent can be utilized in research to analyze the purity of Palbociclib and assess its pharmacological properties in cancer studies.

Cat. No.

A64273

CAS No.

3585-52-2

p-Ethylhydratropic acid

p-Ethylhydratropic acid is identified as a notable impurity found in ibuprofen, which functions as a potent and selective inhibitor of cyclooxygenase-1 (COX-1). Its presence in pharmaceutical formulations is significant for quality control and analytical studies. Research applications may include the characterization of ibuprofen derivatives and the investigation of their respective pharmacological profiles.

Cat. No.

A64555

CAS No.

139272-67-6

Aceclofenac ethyl ester

Aceclofenac ethyl ester is an impurity of the non-steroidal anti-inflammatory drug Aceclofenac, primarily acting through inhibition of cyclooxygenase (COX) enzymes. This compound may serve as a reference standard in pharmacokinetic studies and method development for analyzing Aceclofenac and its related substances. Its characterization contributes to the understanding of the drug's stability and metabolism, aiding in the overall evaluation of therapeutic efficacy and safety profiles.

Cat. No.

A68375

CAS No.

721924-06-7

N3-Methyl pantoprazole

N3-Methyl pantoprazole is an impurity of the proton pump inhibitor Pantoprazole. It serves as a significant reference standard for quality control and analytical research in pharmaceutical development. Its characterization aids in understanding the metabolic pathways and stability of Pantoprazole, providing insight into the safety and efficacy profiles of related compounds. This reagent is essential for researchers examining the pharmacological aspects of proton pump inhibitors.

Cat. No.

A70206

CAS No.

571189-51-0

N-Methyl Palbociclib

N-Methyl Palbociclib is an impurity of Palbociclib, a selective inhibitor of CDK4 and CDK6. This compound is primarily used in analytical studies to assess the purity and quality of Palbociclib formulations. Its relevance in research includes characterization of CDK inhibition and investigations into cell cycle regulation in cancer therapy.

Cat. No.

A70261

CAS No.

2227103-37-7

Rezivertinib analogue 1

Rezivertinib analogue 1 is recognized as a process impurity of osimertinib mesylate, a potent inhibitor of EGFR mutations. This compound serves as a valuable tool in the research of non-small cell lung cancer, facilitating the investigation of drug efficacy and safety profiles in therapeutic applications. Its role in characterizing impurities enhances understanding of the pharmacological landscape surrounding osimertinib-related treatments.

Cat. No.

A70280

CAS No.

1335202-59-9

Febuxostat sec-butoxy acid

Febuxostat sec-butoxy acid is a known impurity of Febuxostat, a selective inhibitor of xanthine oxidase with a Ki of 0.6 nM. This compound serves as a reference standard for analytical and quality control processes in pharmaceutical research. It is essential for investigating the purity and composition of Febuxostat formulations, as well as for understanding the implications of impurities in therapeutic contexts.

Cat. No.

A70290

CAS No.

1105067-93-3

Atorvastatin 3-Deoxyhept-2E-Enoic Acid

Synonyms: (2E)-2,3-Dehydroxy Atorvastatin

Atorvastatin 3-Deoxyhept-2E-Enoic Acid, a known impurity of Atorvastatin, functions primarily as an HMG-CoA reductase inhibitor. This compound plays a critical role in lipid metabolism regulation and is utilized for analysis in pharmaceutical development and quality control of Atorvastatin formulations. Its presence and characterization are essential for ensuring the purity and efficacy of atorvastatin-based therapies to manage hyperlipidemia and cardiovascular diseases.

Cat. No.

A70297

CAS No.

2469279-00-1

Venetoclax N-oxide

Venetoclax N-oxide is an impurity of the Bcl-2 inhibitor Venetoclax (ABT-199; GDC-0199), which exhibits exceptional potency with a Ki value lower than 0.01 nM. This compound serves as a valuable reference for the synthesis and characterization of Venetoclax, and is essential for ensuring the quality and consistency of research involving Bcl-2 modulation. Its analysis is relevant for studies investigating therapeutic applications in hematological malignancies and other conditions associated with dysregulated Bcl-2 activity.

Cat. No.

A70319

CAS No.

34523-34-7

4-Hydroxyacetophenone oxime

4-Hydroxyacetophenone oxime is recognized as an impurity of Acetaminophen (Paracetamol), a widely used antipyretic and analgesic. This compound acts as an inhibitor of cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2), contributing to the pharmacological profile of Acetaminophen. It serves as a useful reference for analytical and quality control studies related to Acetaminophen formulations.

Cat. No.

A70347

CAS No.

253431-35-5

28-Epirapamycin

28-Epirapamycin is an impurity of Rapamycin, a well-characterized inhibitor of the mechanistic target of rapamycin (mTOR). It exhibits potent biological activity with an inhibitory concentration (IC50) of 0.1 nM in HEK293 cells. This compound is primarily utilized for research involving mTOR signaling pathways and cellular growth regulation. It is valuable for studies focused on cancer, metabolic disorders, and age-related diseases.

Cat. No.

A70384

CAS No.

448184-48-3

Vardenafil N-oxide

Vardenafil N-oxide is an N-Oxide impurity of Vardenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor. This compound serves as an important analytical standard for quality control and characterization of Vardenafil formulations in pharmaceutical research. Its presence may impact the pharmacokinetics and efficacy of Vardenafil, making it relevant for studies on drug metabolism and safety assessments.

Cat. No.

A70395

CAS No.

210980-68-0

Anhydrosimvastatin

Synonyms: Dehydro simvastatin

Anhydrosimvastatin is an impurity of Simvastatin, a known competitive inhibitor of HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis. This compound is primarily used in research to assess the purity and quality of Simvastatin preparations. Its characterization is essential for studies evaluating the pharmaceutical formulations and metabolic pathways influenced by cholesterol-lowering therapies.

Cat. No.

A70414

CAS No.

693794-20-6

Difluoro atorvastatin

Synonyms: Fluoroatorvastatin

Difluoro atorvastatin is an impurity of the HMG-CoA reductase inhibitor atorvastatin. This compound demonstrates significant activity by effectively reducing blood lipid levels. Additionally, difluoro atorvastatin is known to inhibit the proliferation and invasion of human smooth muscle cells, exhibiting IC50 values of 0.39 μM and 2.39 μM, respectively. It serves as a useful reference compound in the evaluation of atorvastatin purity and related studies in cholesterol management and cardiovascular research.

Cat. No.

A70551

CAS No.

887196-30-7

3-Oxo Atorvastatin

3-Oxo Atorvastatin is an impurity of atorvastatin, which acts as an HMG-CoA reductase inhibitor. This compound is critical in studying the metabolic pathways associated with cholesterol synthesis and lipid regulation. Its role as an impurity is essential for accurately assessing the purity and efficacy of atorvastatin in pharmaceutical formulations and research applications.

Cat. No.

A70625

CAS No.

887196-29-4

O-Methyl Atorvastatin calcium

O-Methyl Atorvastatin calcium serves as an impurity of Atorvastatin, a well-established 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This compound is primarily utilized in research to study the metabolic effects of HMG-CoA inhibitors and their role in lipid regulation. Its biological activity includes the effective reduction of cholesterol levels, making it significant for investigations into cardiovascular disease and dyslipidemia.