Drug Intermediate

Cat. No.

A48259

CAS No.

19798-81-3

2-Amino-6-bromopyridine

2-Amino-6-bromopyridine acts as a PqsR ligand, exhibiting a dissociation constant (Kd) of 6.8 μM as determined by surface plasmon resonance (SPR) assays. This compound demonstrates weak antagonistic activity and serves as an intermediate in the synthesis of JAK2 and MSK1 inhibitors. Furthermore, 2-Amino-6-bromopyridine is useful in research focused on Pseudomonas aeruginosa infections, contributing to studies aimed at understanding bacterial communication and virulence factors.

Cat. No.

A97530

CAS No.

553-26-4

4,4′-Dipyridyl

4,4′-Dipyridyl is a heterocyclic compound that serves as a versatile bidentate ligand in supramolecular chemistry. This reagent is widely employed as an electronic and photosensitive building block, enabling the development of advanced materials and complex architectures. Additionally, 4,4′-Dipyridyl acts as a critical drug intermediate in the synthesis of paraquat, an extensively used herbicide, facilitating research in agricultural chemistry and environmental science.

Cat. No.

A97633

CAS No.

6163-58-2

Tri(2-methylphenyl)phosphine

Tri(2-methylphenyl)phosphine is an organic phosphorus compound functioning as a ligand that facilitates the formation of metal complexes. Its primary application is as a drug intermediate in pharmaceutical synthesis. The compound's structural characteristics enhance its utility in various coordination chemistry applications, making it a valuable reagent in organic and medicinal chemistry research.

Cat. No.

A97856

CAS No.

637-88-7

1,4-Cyclohexanedione

1,4-Cyclohexanedione serves as a crucial drug intermediate due to its role as a substrate for the EryKR1 domain. This compound exhibits unique biocatalytic activity and stereospecificity, making it valuable for various synthetic applications in pharmaceutical research. Its ability to participate in stereochemical transformations further supports its utility in the development of complex organic molecules.

Cat. No.

A98382

CAS No.

498-62-4

3-Thiophenecarboxaldehyde

Synonyms: 3-TC

3-Thiophenecarboxaldehyde is a thiophene derivative that serves as a substrate for biocatalytic reduction to 3-thiophenemethanol, facilitated by Pseudomonas putida S12 cells. This compound functions as an important intermediate in synthetic pathways. However, it exhibits toxicity toward Pseudomonas putida S12 at elevated concentrations, negatively impacting specific growth rates and final biomass yields. Its unique properties make it useful for research in biocatalysis and metabolic engineering.

Cat. No.

A98748

CAS No.

153226-99-4

LY280748

LY280748 is a potent imidazolate receptor ligand, functioning primarily as a drug intermediate. This compound exhibits significant biological activity, making it a valuable tool in pharmacological research and development. Its application spans various studies focused on receptor-mediated signaling pathways and the synthesis of novel therapeutic agents.

Cat. No.

A98838

CAS No.

174264-46-1

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene is a silyl ether derivative of Raloxifene formed through its reaction with tert-butyldimethylsilyl chloride. This compound plays a crucial role in the synthesis of Raloxifene 6-glucuronide, facilitating studies on Raloxifene metabolism and pharmacokinetics. Its utility in chemical research underscores its significance in the exploration of selective estrogen receptor modulators and their applications in therapeutic contexts.

Cat. No.

B10424

CAS No.

863238-52-2

Sal-AMP

Sal-AMP is an acyl-adenylate intermediate that serves as a substrate for MbtA, facilitating the loading onto the thiolation domain of MbtB. This compound plays a critical role in the biosynthetic pathway of mycobacterial compounds and is valuable for research investigating tuberculosis and related bacterial processes. Its use can aid in understanding the mechanisms of mycobacterial metabolism and potential drug targets.

Cat. No.

B21764

CAS No.

87-41-2

Phthalide

Phthalide is a versatile chemical scaffold known for its potential in synthesizing various derivatives with significant biological activities. Its derivatives have been explored for applications as anti-inflammatory agents, antimicrobial compounds, antioxidants, and modulators of the blood-tumor barrier. Phthalide serves as a foundational structure in medicinal chemistry, facilitating the development of novel therapeutic agents.