Impurities & Reference Standards

Cat. No.

A29367

CAS No.

1566571-64-9

25I-NBOMe 4-methoxy isomer hydrochloride

25I-NBOMe 4-methoxy isomer hydrochloride is a potent agonist of the 5-HT2A receptor. It exhibits high affinity for both rat and human 5-HT2A receptors, with binding affinities (Ki values) of 0.087 nM and 0.044 nM, respectively. This compound is utilized in research exploring serotonergic mechanisms and their implications in neuropharmacology, particularly in studies related to psychotropic effects and receptor signaling pathways.

Cat. No.

A31200

CAS No.

10378-06-0

(6R)-FR054

(6R)-FR054 is a less active isomer of FR054, acting primarily as a modulator of biological pathways influenced by the parent compound. This reagent provides a valuable tool for comparative studies aimed at elucidating the mechanisms of action and specific contributions of the more active isomer. Researchers can utilize (6R)-FR054 in the development of experimental designs that require an understanding of molecular interactions and signaling processes.

Cat. No.

A34199

CAS No.

79313-75-0

Sopromidine

Sopromidine is a potent stereoselective isomer of the achiral H2-agonist Impromidine. It exhibits significant activity as a histamine H2 receptor agonist, influencing gastric acid secretion and various physiological processes. This reagent is primarily utilized in research focused on gastrointestinal physiology and pharmacology, facilitating studies on the modulation of histaminergic pathways.

Cat. No.

A40166

CAS No.

127810-07-5

WAY-120744

WAY-120744 is a novel naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxide that acts as a potent modulator of biological targets relevant to chemotherapeutic strategies. This compound demonstrates significant anti-cancer activity, making it suitable for applications in cancer research and drug development. Its unique structure permits exploration of mechanisms of action in various cellular contexts, providing valuable insights into the modulation of signaling pathways.

Cat. No.

A59491

CAS No.

2649575-19-7

(Rac)-Upacicalcet

Synonyms: (Rac)-SK-1403 free acid; (Rac)-AJT240 free acid; (Rac)-PLS240 free acid

(Rac)-Upacicalcet serves as a racemic compound of Upacicalcet, a non-peptide calcimimetic that functions as an agonist of the calcium-sensing receptor (CaSR) with an EC50 of 10.8 nM. This compound has been shown to effectively lower serum intact parathyroid hormone (iPTH) and calcium levels, thereby mitigating hypocalcemia and associated gastrointestinal issues. In research models of secondary hyperparathyroidism (SHPT) induced by adenine, (Rac)-Upacicalcet demonstrates potential in improving vascular calcification and alleviating bone disorders. Its inhibitory effects on cortical pore formation and bone fibrosis have been noted in studies involving chronic kidney disease (CKD) models, making it a valuable tool for investigating SHPT mechanisms.

Cat. No.

A60855

CAS No.

1609563-70-3

(1S,2S)-2-PCCA hydrochloride

(1S,2S)-2-PCCA hydrochloride is a diastereomer of 2-PCCA that serves as a selective GPR88 receptor agonist. This compound effectively inhibits GPR88-mediated cAMP production, demonstrating an EC50 of 116 nM in HEK293 cells. It is useful in research applications focused on GPR88-related signaling pathways and neurological studies.

Cat. No.

A65911

CAS No.

319-78-8

D-Isoleucine

Synonyms: (R)-Isoleucine

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter, exhibiting a Ki value of 0.98 mM. By binding to the Asc-1 protein on neuronal cell membranes, D-Isoleucine facilitates the release of D-serine and glycine, thereby enhancing NMDA receptor-dependent synaptic plasticity. This compound is relevant in the study of neurodegenerative diseases, including Alzheimer's disease and schizophrenia. Additionally, D-Isoleucine serves as a non-classical D-amino acid, disrupting bacterial peptidoglycan synthesis and inhibiting biofilm formation in Staphylococcus aureus, suggesting its potential utility in antibacterial research.

Cat. No.

A74950

CAS No.

1191996-10-7

(S,S)-Sinogliatin

Synonyms: (S,S)-HMS-5552; (S,S)-RO-5305552

(S,S)-Sinogliatin is the (S,S)-enantiomer of the glucokinase activator Sinogliatin, specifically targeting glucokinase to enhance its activity. This compound demonstrates significant potential in the modulation of glucose metabolism, making it a valuable tool for research applications related to type 2 diabetes. Its use can aid in investigating the therapeutic mechanisms underlying glucose homeostasis and pancreatic function.

Cat. No.

B21627

CAS No.

80-75-1

11alpha-Hydroxyprogesterone

11alpha-Hydroxyprogesterone is an isomer of 11beta-Hydroxyprogesterone, serving as a valuable experimental control in research. It exhibits biological activity as a modulator of steroid receptors and can be utilized to investigate the effects of glucocorticoids and mineralocorticoids in cellular systems. Its application includes studying the activation of human mineralocorticoid receptors and the inhibition of 11β-Hydroxysteroid dehydrogenase, facilitating a deeper understanding of steroid hormone signaling pathways.