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Impurities & Reference Standards

Impurities & Reference Standards collects environmental contaminants, industrial chemicals and drug stereoisomers. Many entries are substances monitored in environmental and food analysis, such as the plasticizer dimethyl phthalate and the polycyclic aromatic hydrocarbon fluorene. Flame retardants are represented by the organophosphate triphenyl phosphate and by brominated compounds. Perfluorodecanoic acid belongs to the per- and polyfluoroalkyl substances (PFAS), a class known for persistence in the environment. A second group holds enantiomers and isomers of research compounds, such as (R)-Asundexian, the (R)-enantiomer of the factor XIa inhibitor asundexian. Such isomers support stereochemical comparison and the development of chromatographic separation methods. Process-related and degradation compounds of individual drugs are listed separately under Drug Impurity.

3 Items

  • D-Isoleucine
    Cat. No.
    A65911
    CAS No.
    319-78-8

    D-Isoleucine

    Synonyms: (R)-Isoleucine

    D-Isoleucine is a selective competitive activator of the Asc-1 antiporter, exhibiting a Ki value of 0.98 mM. By binding to the Asc-1 protein on neuronal cell membranes, D-Isoleucine facilitates the release of D-serine and glycine, thereby enhancing NMDA receptor-dependent synaptic plasticity. This compound is relevant in the study of neurodegenerative diseases, including Alzheimer's disease and schizophrenia. Additionally, D-Isoleucine serves as a non-classical D-amino acid, disrupting bacterial peptidoglycan synthesis and inhibiting biofilm formation in Staphylococcus aureus, suggesting its potential utility in antibacterial research.

    In stock View Details
    25 mg
    $35.00
    50 mg
    $55.00
    All 6 sizes
  • (Rac)-Methylindazone
    Cat. No.
    A66546
    CAS No.
    53108-00-2

    (Rac)-Methylindazone

    Synonyms: (Rac)-IAA-94

    (Rac)-Methylindazone is the racemic mixture of Methylindazone, a potent blocker of the CLIC1 ion channel. This compound exhibits significant biological activity in modulating chloride ion transport, making it a valuable tool in research focused on ion channel function and related physiological processes. Potential applications include studies in cellular signaling and the investigation of CLIC1's role in various pathophysiological conditions.

    In stock View Details
    25 mg
    $1,405.00
    50 mg
    $1,790.00
    All 3 sizes
  • (S,S)-Sinogliatin
    Cat. No.
    A74950
    CAS No.
    1191996-10-7

    (S,S)-Sinogliatin

    Synonyms: (S,S)-HMS-5552; (S,S)-RO-5305552

    (S,S)-Sinogliatin is the (S,S)-enantiomer of the glucokinase activator Sinogliatin, specifically targeting glucokinase to enhance its activity. This compound demonstrates significant potential in the modulation of glucose metabolism, making it a valuable tool for research applications related to type 2 diabetes. Its use can aid in investigating the therapeutic mechanisms underlying glucose homeostasis and pancreatic function.

    In stock View Details
    1 mg
    $180.00
    5 mg
    $560.00
    All 6 sizes

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