PC945 is a potent antifungal triazole that targets the sterol 14α-demethylase enzymes CYP51A and CYP51B in Aspergillus fumigatus, demonstrating strong inhibitory activity with IC50 values of 0.23 μM and 0.22 μM, respectively. This compound exhibits efficacy against a wide variety of both azole-susceptible and azole-resistant strains of A. fumigatus. PC945 is of significant interest in antifungal research and offers potential applications in the treatment of invasive fungal infections.
PC945 is a potent antifungal triazole that targets the sterol 14α-demethylase enzymes CYP51A and CYP51B in Aspergillus fumigatus, demonstrating strong inhibitory activity with IC50 values of 0.23 μM and 0.22 μM, respectively. This compound exhibits efficacy against a wide variety of both azole-susceptible and azole-resistant strains of A. fumigatus. PC945 is of significant interest in antifungal research and offers potential applications in the treatment of invasive fungal infections.
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