PF-543 Citrate

Catalog No.: A15210

SphK1 Inhibitor

PF-543 Citrate

PF-543 Citrate Chemical Structure

CAS NO. 1415562-83-2

PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $64.00

10 mg

Regular Price: $125.00

Special Price $100.00

50 mg

Regular Price: $495.00

Special Price $396.00

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Biological Activity

PF-543 Citrate is a novel cell-permeant inhibitor of SphK1 with a K(i) of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
In vitro DMSO 85 mg/mL (169.3 mM)
Water Insoluble
Ethanol 85 mg/mL (169.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.2 mL 76.02 mL 152.04 mL
0.5 mM 3.04 mL 15.2 mL 30.41 mL
1 mM 1.52 mL 7.6 mL 15.2 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 657.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15210
Actions Inhibitor
CAS No. 1415562-83-2
Formula C33H39NO11S
M. Wt 657.73
Purity >98%
Synonyms PF543 Citrate, PF 543 Citrate
SMILES CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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