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Akt inhibitors target Akt, also called protein kinase B (PKB), a serine/threonine kinase in cell survival signaling. In 1995 the Akt proto-oncogene product was identified as a target of phosphatidylinositol 3-kinase (PI3K) activated by platelet-derived growth factor. Insulin and insulin-like growth factor 1 activate the kinase through phosphorylation at Thr308 and Ser473. The three isoforms, Akt1, Akt2 and Akt3, phosphorylate substrates that control metabolism, proliferation and apoptosis. The category includes the allosteric inhibitor MK-2206 2HCl, the catalytic-site inhibitor capivasertib and the alkylphospholipid perifosine. SC79, by contrast, promotes Akt phosphorylation and serves as an activator in pathway studies.
AS1938909 is a selective Akt inducer that inhibits SHIP2 activity, leading to increased phosphorylation of Akt. This compound plays a crucial role in the regulation of glucose metabolism by upregulating GLUT1 gene expression. AS1938909 is valuable for research applications focused on metabolic disorders and signaling pathways involving Akt and SHIP2.
