AMPK | Adooq Bioscience

Cat. No.: A37027

CAS No.: 2170935-59-6

HSF1/AMPK activator 1

HSF1/AMPK activator 1 is a potent modulator of the HSF1/AMPK axis, targeting the TGF-β1/Smad signaling pathway. This compound demonstrates significant anti-hepatic fibrosis activity by inhibiting fibrosis formation and cell proliferation in activated hepatic stellate cells. Additionally, HSF1/AMPK activator 1 effectively alleviates liver injury and symptoms of hepatic fibrosis in fibrotic mouse models. It is a valuable tool for research focused on hepatic fibrosis and related metabolic disorders.

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Cat. No.: A39463

CAS No.: 28500-04-1

Malvidin-3-O-arabinoside chloride

Malvidin-3-O-arabinoside chloride is an AMPK inducer that enhances cellular autophagy. This compound is recognized for its ability to mitigate oxidative damage induced by ethyl carbamate through the activation of AMPK signaling pathways. Its biological activity supports research applications focused on metabolic disorders and oxidative stress-related conditions.

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Cat. No.: A57640

CAS No.: 125911-68-4

SAMS

SAMS peptide is a specific substrate for AMP-activated protein kinase (AMPK), facilitating the investigation of AMPK activation and its downstream signaling pathways. This peptide plays a critical role in metabolic research, allowing for the study of energy homeostasis and cellular responses to stress. SAMS is essential for probing the physiological effects of AMPK modulation in various biological contexts.

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Cat. No.: A57669

CAS No.: 2711012-08-5

CB1R/AMPK modulator 1

CB1R/AMPK Modulator 1 is a potent modulator of the cannabinoid receptor type 1 (CB1R) and adenosine monophosphate-activated protein kinase (AMPK), exhibiting a Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound effectively activates AMPK, leading to significant reductions in food intake and body weight. Additionally, it enhances glucose tolerance and insulin sensitivity, making it a valuable tool for research in metabolic disorders and obesity-related studies.

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Cat. No.: A57684

CAS No.: 3019920-38-5

4-PivO-NMT chloride

4-PivO-NMT chloride is an indole-derived modulator of the AMPK signaling pathway, specifically influencing neurogenesis and neurite outgrowth by regulating AMPK activity. Its biological activity suggests potential applications in studying neurological disorders, pain mechanisms, and inflammatory responses. This compound serves as a valuable tool for researchers investigating the role of AMPK in various cellular processes.

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Cat. No.: A72504

CAS No.: 652968-37-1

MitoPBN

MitoPBN is an AMPK/SIRT3/PGC-1α modulator that enhances mitochondrial function by acting as a reactive oxygen species scavenger. This compound promotes mitochondrial biogenesis through increased AMPK phosphorylation, restoration of SIRT3 expression, and upregulation of PGC-1α. MitoPBN is effective in regulating glucose metabolism, as it decreases blood glucose levels by inhibiting hepatic gluconeogenesis and enhancing glucose uptake, while also improving ATP production and maintaining mitochondrial membrane potential. Additionally, it can reduce apoptosis and enhance sperm motility and membrane integrity, making it a valuable reagent for research related to diabetes and metabolic disorders.

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